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Preoperative neutrophil-to-lymphocyte ratio (NLR) predicts poor outcomes in high-risk cutaneous squamous cell carcinoma, offering a cost-effective tool to enhance risk stratification.
This study validates the prognostic accuracy of the 15-gene expression profiling (15-GEP) and PRAME assay in uveal melanoma patients irrespective of confirmatory cytopathology, supporting its use in clinical management when cytopathology is
This study establishes transthyretin amyloid cardiomyopathy-specific mitral regurgitation thresholds, revealing lower severity cutoffs than guidelines and enhancing mortality and heart failure hospitalization risk prediction.
The COMPASS-SCC, developed from a large international cohort, offers improved prognostic accuracy for cutaneous squamous cell carcinoma compared to existing AJCC8 and BWH staging systems, aiding clinical decision-making for metastasis and m
Systemic relapse after stage I melanoma, though rare, portends higher tumor burden and poorer survival compared with relapse after stage II/III disease, as evidenced by data from 365 metastatic melanoma patients in the Spanish Melanoma Regi
Telomere length serves as an independent prognostic marker for progression-free survival in chronic lymphocytic leukemia patients treated with venetoclax-based regimens, highlighting its role in risk stratification during the modern targete
Age-adjusted WGS-estimated telomere length improves identification of pathologically short telomeres and detection of telomere-related variants in IPF, associating with survival outcomes but offering limited survival prediction beyond clini
A polygenic risk score (PRS) significantly associates with IPF diagnosis and mortality, demonstrating potential for improving clinical risk stratification using real-world biobank data.
The INTERCEPT study demonstrates that longitudinal ctDNA testing effectively detects minimal residual disease post-curative treatment in colorectal cancer, enhancing recurrence prediction and refining risk stratification to guide future int
Most heart failure patients harbor multiple cardiovascular-kidney-metabolic conditions, which independently escalate mortality and readmission risk, especially in HFrEF, underscoring the need for integrated management strategies tailored by
Soluble BCMA levels in newly diagnosed multiple myeloma patients reveal distinct tumor phenotypes and predict prognosis more strongly than tumor volume, enabling improved risk stratification and clinical decision-making.
This large nationwide study demonstrates that coronary CTA-derived FFR-CT strongly predicts future myocardial infarction, cardiovascular death, and revascularization, independent of traditional risk factors and stenosis severity, with a thr
This study demonstrates that elevated brain natriuretic peptide (BNP) post-pulmonary endarterectomy strongly predicts mortality in chronic thromboembolic pulmonary hypertension (CTEPH), providing valuable prognostic information beyond persi
This study highlights how HPV and TP53 molecular subtyping in stage I vulvar squamous cell carcinoma delineates survival outcomes and recurrence risks, supporting its role in personalized management strategies.
The MYSTICS Registry provides robust data on cardiac sarcoidosis, highlighting diagnostic challenges, treatment patterns, and prognostic differences among phenotypes, emphasizing tailored management strategies to improve patient outcomes.
Older adults with severe nerve impairment in Bell’s palsy experience markedly poorer recovery, highlighting the critical role of early, aggressive intervention.
Electrodiagnostic tests, notably electroneuronography and electromyography, significantly improve prognosis prediction for Bell palsy recovery, including patients with moderate paralysis (H-B grade IV). These findings support broader use to
This article explores how genetic variants affect CPEB3-mediated alternative polyadenylation in hepatocellular carcinoma, revealing potential prognostic markers and therapeutic targets to improve patient survival.
A shift from static portal pressure thresholds to dynamic, non-invasive risk prediction models offers improved prognostic accuracy for decompensation in advanced chronic liver disease, enabling personalized patient management and better cli
Baseline cortical atrophy within an EOAD-specific brain signature predicts progression from mild cognitive impairment to dementia, providing a valuable MRI biomarker for individualized prognosis in early-onset Alzheimer disease.
