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Pathologic Myopia Globe Shape and Long-Term Prognosis
newseye shapehigh myopia

Pathologic Myopia Globe Shape and Long-Term Prognosis

By MedXY|Jun 1, 2026

Three-dimensional eye shape on MRI predicted 15-year outcomes in high myopia. Nasally distorted and conical eyes had the highest risk of rapid elongation, macular thinning, myopic degeneration, and visual field defects.

TP53 Multihit Does Not Fully Erase the Prognostic Advantage of Isolated del(5q) in Myelodysplastic Neoplasms
Hematology-Oncologydel(5q)MDS

TP53 Multihit Does Not Fully Erase the Prognostic Advantage of Isolated del(5q) in Myelodysplastic Neoplasms

© 2026 MedXY
Contact usAbout usPrivacy PolicyMedXY story
By MedXY|May 9, 2026

A multicenter retrospective study suggests that MDS with isolated del(5q) and TP53 multihit alterations has substantially better survival than other low-blast TP53-multihit MDS, challenging how this subgroup should be classified.

Mild and Single Moderate COPD Exacerbations Predict Future Risks: Insights from a Community-Based Cohort Study
Internal MedicineCOPDexacerbations

Mild and Single Moderate COPD Exacerbations Predict Future Risks: Insights from a Community-Based Cohort Study

By MedXY|Apr 27, 2026

Community-based COPD patients with mild or single moderate exacerbations show higher future exacerbation risks and lung structural abnormalities, despite stable lung function decline rates.

Inflammatory Biomarkers in Cerebral Venous Thrombosis: Prognostic Insights from the CLOT-VENUS Substudy and Meta-Analyses
Clinical UpdatesCerebral Venous ThrombosisInflammatory Biomarkers

Inflammatory Biomarkers in Cerebral Venous Thrombosis: Prognostic Insights from the CLOT-VENUS Substudy and Meta-Analyses

By MedXY|Apr 24, 2026

High admission levels of NLR, PLR, MLR, and SII are independently associated with poor functional outcomes and mortality in acute cerebral venous thrombosis, offering a low-cost tool for early risk stratification.

Right Ventricular to Pulmonary Artery Coupling: A New Prognostic Marker in Heart Failure Therapy
CardiologyGDMTheart failure

Right Ventricular to Pulmonary Artery Coupling: A New Prognostic Marker in Heart Failure Therapy

By MedXY|Apr 22, 2026

A study reveals that RV-PA coupling, measured by TAPSE/sPAP ratio, significantly predicts outcomes in HFrEF patients during GDMT up-titration, highlighting its potential as a treatment target.

Novel Fusion Model Combines Hypoxia and Immune Signatures to Predict Survival in HCC Patients Undergoing TACE Therapy
Gastroenterologyfusion modelhepatocellular carcinoma

Novel Fusion Model Combines Hypoxia and Immune Signatures to Predict Survival in HCC Patients Undergoing TACE Therapy

By MedXY|Apr 2, 2026

A groundbreaking multicentre study develops a clinical-radiologic model integrating hypoxia and immune phenotype signatures to accurately predict prognosis in hepatocellular carcinoma patients treated with transarterial chemoembolisation, p

Beyond the Restrictive Paradigm: Redefining Left Ventricular Phenotypes and Prognosis in Cardiac Amyloidosis
Cardiologyechocardiographyheart failure

Beyond the Restrictive Paradigm: Redefining Left Ventricular Phenotypes and Prognosis in Cardiac Amyloidosis

By MedXY|Mar 2, 2026

A large-scale retrospective study challenges the classic view of cardiac amyloidosis, revealing that while restriction is the dominant phenotype at diagnosis, nearly one-third of patients present with preserved function, and progression pat

Post-TIA Depression: A Silent Predictor of Mortality and Long-Term Disability Independent of Brain Ischemia
Neurologyprognosistransient ischemic attack

Post-TIA Depression: A Silent Predictor of Mortality and Long-Term Disability Independent of Brain Ischemia

By MedXY|Jan 7, 2026

A population-based study reveals that nearly one-quarter of TIA patients experience depression, which significantly increases the risk of mortality and disability, regardless of whether acute ischemic lesions are present on imaging.

Hypermagnesemia as a Potent Predictor of Adverse Outcomes in Heart Failure: New Evidence from the GALACTIC-HF Trial
CardiologyGALACTIC-HFheart failure

Hypermagnesemia as a Potent Predictor of Adverse Outcomes in Heart Failure: New Evidence from the GALACTIC-HF Trial

By MedXY|Jan 1, 2026

A secondary analysis of the GALACTIC-HF trial demonstrates that hypermagnesemia, rather than hypomagnesemia, is significantly associated with increased cardiovascular death and worsening heart failure in patients with HFrEF, challenging cur

Cervical Stromal Invasion Does Not Independently Predict Survival in Early-Stage Endometrial Cancer: A Multicenter Analysis
newsEndometrial Cancerprognosis

Cervical Stromal Invasion Does Not Independently Predict Survival in Early-Stage Endometrial Cancer: A Multicenter Analysis

By MedXY|Dec 25, 2025

A large-scale multicenter study indicates that cervical stromal invasion is not an independent prognostic factor for survival in early-stage endometrial cancer, challenging traditional staging assumptions when other high-risk features are c

Frailty after Acute Myocardial Infarction: A Stronger Predictor of 1‑Year Death in Younger Patients Than in the Elderly
Cardiologyacute myocardial infarctionFrailty

Frailty after Acute Myocardial Infarction: A Stronger Predictor of 1‑Year Death in Younger Patients Than in the Elderly

By MedXY|Dec 2, 2025

A large population study shows frailty is independently linked to worse 1‑year outcomes after AMI across ages, with the largest relative impact in patients under 55 — underscoring the need to assess frailty beyond geriatric populations.

A Standardized RANO Resection Classification Links Supramaximal Surgery to Meaningful Survival Gains in IDH‑Mutant Grade 2 Glioma
Neurologyprognosis

A Standardized RANO Resection Classification Links Supramaximal Surgery to Meaningful Survival Gains in IDH‑Mutant Grade 2 Glioma

By MedXY|Nov 29, 2025

An international retrospective cohort (n=1,391) validates a four‑tier RANO classification of residual T2‑FLAIR volume: supramaximal resection confers the largest survival benefit, with graded, durable advantages for maximal versus submaxima

Lean MASLD Is Not Benign: Higher Liver Events and Mortality in Normal-BMI Patients Across Three Large Cohorts
GastroenterologyMASLDMortality

Lean MASLD Is Not Benign: Higher Liver Events and Mortality in Normal-BMI Patients Across Three Large Cohorts

By MedXY|Nov 7, 2025

A pooled analysis of three population cohorts shows lean MASLD carries higher risks of liver-related events and all-cause and liver-related mortality despite lower cardiovascular event risk compared with non-lean MASLD.

Unraveling Non-Acute Decompensation in Cirrhosis: A Distinct Clinical and Pathophysiological Entity with Prognostic Implications
Gastroenterologycirrhosisprognosis

Unraveling Non-Acute Decompensation in Cirrhosis: A Distinct Clinical and Pathophysiological Entity with Prognostic Implications

By MedXY|Oct 28, 2025

Non-acute decompensation of cirrhosis (NAD) represents a distinct clinical state characterized by elevated cell death markers and moderate prognosis. Identifying predictors such as ascites severity and biomarkers Gasdermin-D and RIPK3 may g

RIPK3 as a Prognostic Biomarker in Acute Decompensation of Cirrhosis: Advancing Risk Stratification and Therapeutic Targeting
Critical CareACLFbiomarker

RIPK3 as a Prognostic Biomarker in Acute Decompensation of Cirrhosis: Advancing Risk Stratification and Therapeutic Targeting

By MedXY|Oct 28, 2025

RIPK3-associated necroptosis critically drives organ failure and mortality in acute decompensation and ACLF, with its plasma levels robustly predicting outcomes and improving prognostic models to guide personalized therapies.

Artificial Intelligence in Imaging-Based Extranodal Extension Detection: Advancing Prognostication in HPV-Positive Oropharyngeal Cancer
AIartificial intelligenceExtranodal Extension

Artificial Intelligence in Imaging-Based Extranodal Extension Detection: Advancing Prognostication in HPV-Positive Oropharyngeal Cancer

By MedXY|Oct 22, 2025

An AI-driven model accurately detects imaging-based extranodal extension in HPV-positive oropharyngeal cancer from CT scans, improving outcome prediction beyond expert radiologist assessments and identifying patients at higher risk of poore

Ki-67 Dynamics During Neoadjuvant Chemotherapy: A Key to Better Breast Cancer Prognosis
Hematology-Oncologybreast cancerneoadjuvant chemotherapy

Ki-67 Dynamics During Neoadjuvant Chemotherapy: A Key to Better Breast Cancer Prognosis

By MedXY|Oct 18, 2025

This study highlights the prognostic significance of tumor Ki-67 changes during neoadjuvant treatment, offering potential for improved risk stratification and personalized therapy in breast cancer patients.

Restrictive Treatment Criteria Improve Prognosis Prediction in Chronic Lymphocytic Leukemia: Insights from the Brazilian Registry
Hematology-Oncologyprognosis

Restrictive Treatment Criteria Improve Prognosis Prediction in Chronic Lymphocytic Leukemia: Insights from the Brazilian Registry

By MedXY|Oct 18, 2025

A restrictive treatment initiation approach in CLL, endorsed by the Brazilian Group of CLL, identifies patients with higher risk more accurately and spares low-risk patients from unnecessary therapy, showing superior prognostic stratificati

Assessing the Nationwide Prevalence and Outcomes of Breast Cancer Patients Eligible for Adjuvant CDK4/6 Inhibitors
OB/GYN & Women's Healthbreast cancerCDK4/6 inhibitors

Assessing the Nationwide Prevalence and Outcomes of Breast Cancer Patients Eligible for Adjuvant CDK4/6 Inhibitors

By MedXY|Oct 18, 2025

This study offers insights into the prevalence, characteristics, and long-term survival of breast cancer patients eligible for adjuvant CDK4/6 inhibitors, highlighting real-world outcomes compared to clinical trial populations.

Large-Cell Transformation of Mycosis Fungoides: Clinical Patterns, Prognostic Insights, and Implications for Staging
DermatologyCutaneous lymphomaMycosis fungoides

Large-Cell Transformation of Mycosis Fungoides: Clinical Patterns, Prognostic Insights, and Implications for Staging

By MedXY|Oct 14, 2025

Large-cell transformation in mycosis fungoides marks an aggressive disease subset with distinct prognostic groups and poor survival, highlighting the need for tailored treatment and integration into staging systems.

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