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This review synthesizes evidence from a large US network study on patient-reported postoperative dental pain, medication use, and functional interference, highlighting procedure-specific pain trajectories and opioid stewardship implications
In a randomized trial, sodium citrate as an anticoagulant in concentrated growth factor therapy for androgenetic alopecia reduced injection pain, improved hair density, and increased patient satisfaction compared with heparin sodium or no a
Aquatic plyometric exercises significantly improve pain, muscle strength, and quality of life in adolescents with patellofemoral pain syndrome, offering a safe and effective rehabilitation option.
This phase III study demonstrates that elagolix is non-inferior to dienogest in reducing moderate-to-severe endometriosis pain, with comparable safety and tolerability profiles, supporting elagolix as a valuable treatment option.
A recent double-blind, placebo-controlled trial found that non-enteric-coated pancreatic enzyme therapy does not significantly reduce pain in chronic pancreatitis patients, highlighting the need to revisit pain management strategies in this
A randomized trial found telehealth mindfulness group visits improve chronic low back pain more than usual care, highlighting a scalable, non-drug treatment option.
The MIPI trial demonstrates that preemptive multidose ibuprofen substantially reduces pain during intrauterine device (IUD) insertion, highlighting a practical approach to enhance patient comfort and potentially increase IUD acceptability.
A quadruple-blinded RCT found that oral dexamethasone given after pediatric tonsillectomy modestly reduced pain and substantially lowered opioid prescriptions, without increasing complications.
This randomized placebo-controlled trial demonstrates that inhaled nitrous oxide significantly reduces pain and enhances patient satisfaction during office operative hysteroscopy, especially in postmenopausal women, while improving procedur
A randomized clinical trial found that electroacupuncture reduced pain more than sham treatment in postherpetic neuralgia, with benefits lasting at least one month and no major safety concerns.
A national study reveals significant state-level and urban-rural variations in opioid prescribing following toothache diagnoses, with 15 states exceeding the national average and rural areas showing slightly lower prescription rates.
This review synthesizes new evidence on endometriosis symptom flares, highlighting a significant gap between patient burden and professional guidance, while integrating the latest meta-analytic findings on pharmacologic pain interventions.
The PROP OA trial demonstrates that adding compartment-specific knee bracing and adherence support to standard exercise and advice significantly improves pain and function in patients with knee osteoarthritis, offering a safe and effective
New clinical trials reveal that adding acetaminophen or hydromorphone to ibuprofen provides no additional pain relief for children with acute musculoskeletal injuries, while the addition of opioids significantly increases the risk of advers
A large-scale cluster-randomized trial involving 1,507 patients demonstrated that adding PECS I blocks to paravertebral or serratus anterior plane blocks does not reduce postoperative opioid use or improve recovery compared to paravertebral
The RESOLVE trial demonstrates that graded sensorimotor retraining provides modest pain relief for chronic low back pain. A secondary analysis reveals that these benefits are consistent across most patient subgroups, suggesting that the int
A comprehensive meta-analysis of 226 publications involving 183,285 patients reveals a significant reduction in ICU delirium and pain following the 2013 PAD guidelines, though prevalence remains high at approximately 36% and 44%, respective
A randomized trial demonstrates that continuous erector spinae plane block provides comparable analgesia to opioid regimens after VATS, while significantly improving patient recovery scores and reducing postoperative complications.
Evidence shows misoprostol rarely improves routine IUD placement outcomes but may benefit women with prior failed attempts.
Oral progestagens likely reduce overall pain and dysmenorrhoea in endometriosis, but comparative benefits over other hormonal treatments remain uncertain.
