Meta-analysis of 14 randomized controlled trials shows misoprostol provides little to no benefit in reducing pain or improving provider ease during routine IUD placement.
Significant side effects include increased abdominal cramping and diarrhea prior to placement.
Women with previous failed IUD placement attempts may experience improved placement success rates when given misoprostol.
Routine use is not recommended for all patients due to limited benefit and increased adverse effects.
Background
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