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Among older adults receiving CAR-T therapy, 5.8% experienced major adverse cardiovascular events (MACE), associated with increased mortality. Pre-existing cardiac conditions heightened risk, underscoring the need for cardiovascular monitori
This study analyzes how the balance between operative and nonoperative management in emergency general surgery for older adults relates to their odds of discharge home, proposing ONR as a novel quality benchmark beyond traditional metrics.
Long-term cumulative exposure to wildfire smoke PM2.5 significantly increases cardiovascular hospitalizations among U.S. older adults, with notable risks in ischemic heart disease and arrhythmias, highlighting the need for targeted public h
This study demonstrates that using the MiniMed 780G hybrid closed-loop system significantly improves glycaemic management and shows a trend toward better microvascular function in adults aged 65 and above with type 1 diabetes, without incre
This study identifies baseline frailty, organ dysfunction severity, and corticosteroid use as independent predictors of severe post-intensive care frailty in older septic shock survivors, highlighting critical factors for targeted post-ICU
Changes in NT-proBNP levels over three years define heart stress status, which improves cardiovascular and mortality risk prediction in older adults without prior CVD, underscoring its utility in clinical risk stratification.
This study investigates whether recurrent hospitalizations mediate the association of postoperative delirium with long-term cognitive decline in seniors after major surgery, finding that rehospitalization does not significantly affect this
A systematic review and meta-analysis of 18 RCTs found that high-intensity resistance training significantly improved leg press and extension strength in adults aged 50+ compared to low-moderate intensity, with similar effects on bone density and no significant difference in fall incidence or adverse events.
This study develops and compares predictive models incorporating claims and patient-reported data to forecast time to first opioid use disorder (OUD) or overdose (OD) among older adults with chronic pain on opioids, identifying key risk fac
This review synthesizes current evidence on the effectiveness of adjuvanted RSVPreF3 vaccination in reducing RSV-related hospitalizations among older US adults, highlighting substantial protection across high-risk subgroups.
Older adults with MASLD, especially those aged 75 and above, experience a high burden of polypharmacy linked to multimorbidity, necessitating careful medication management to balance disease control and geriatric vulnerabilities.
The PREVUE-VALVE study reveals a significant prevalence of moderate or greater valvular heart disease among U.S. adults aged 65-85, highlighting substantial public health implications and the value of decentralized echocardiographic screeni
A multicenter randomized trial found that 4-week multimodal prehabilitation added to ERAS reduced 90-day complications after spinal fusion in adults aged 75 years or older.
A Japanese registry study of 929 patients aged 70+ identified six predictors of worse survival after allo-HSCT and created a simple score that sharply stratified 2-year overall survival from 57.1% to 2.5%.
A large U.S. study found that even PM2.5 levels below current federal standards were linked to higher hypertension hospitalization risk in older adults, especially among women and some regional and socioeconomic groups.
Among more than 26 million older U.S. adults, even PM2.5 levels below current standards were linked to higher hypertension hospitalization risk, suggesting no clearly safe low-exposure threshold.
A large multisite cohort found delirium in 16% of older adults in the emergency department, including nearly 8% of those discharged, with strong links to dementia, acuity, hospitalization, and 30-day readmission.
A large multi-site cohort found delirium in 16% of older ED patients, including many discharged home, and linked it to higher admission and 30-day readmission, underscoring the need for standardized screening and supportive care.
A large U.S. study found that a contrast sensitivity score of 1.60 logCS marks the point where older adults are more likely to experience everyday vision disability, even when standard visual acuity may seem acceptable.
In older adults with limited small vessel disease, “dirty-appearing” white matter on MRI was not linked to baseline cognition, cognitive decline, or dementia risk, unlike conventional white matter hyperintensities.