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Rates of Systemic Treatment for Metastatic Non-Small Cell Lung Cancer Among Older Adults
newsbiomarker testingmetastatic NSCLC

Rates of Systemic Treatment for Metastatic Non-Small Cell Lung Cancer Among Older Adults

By MedXY|May 12, 2026

A population-based study of older adults with metastatic NSCLC found that fewer than half received systemic treatment, with only slight improvement over time. Oncology referral and biomarker testing were strongly linked to treatment, while

Systemic Treatment Remains Underused in Older Adults With Metastatic Non-Small Cell Lung Cancer
newsbiomarker testingmetastatic non-small cell lung cancer

Systemic Treatment Remains Underused in Older Adults With Metastatic Non-Small Cell Lung Cancer

By MedXY|May 12, 2026

A large SEER-Medicare study found that fewer than half of older adults with metastatic NSCLC received systemic therapy, with only modest improvement from 2006 to 2021. Specialist referral and biomarker testing were strongly linked to treatm

Coronary Revascularization in Older Adults: Key Recommendations from the 2025 AHA Scientific Statement
CardiologyFrailtyolder adults

Coronary Revascularization in Older Adults: Key Recommendations from the 2025 AHA Scientific Statement

By MedXY|Dec 25, 2025

The 2025 AHA scientific statement provides practical, patient-centered guidance for coronary revascularization in older adults, emphasizing geriatric assessment, individualized strategy selection, and shared decision-making.

Stepping Down Antihypertensives in Frail Nursing-Home Residents Did Not Reduce Mortality: Results from the RETREAT-FRAIL Trial
CardiologyFrailtynursing home

Stepping Down Antihypertensives in Frail Nursing-Home Residents Did Not Reduce Mortality: Results from the RETREAT-FRAIL Trial

By MedXY|Dec 6, 2025

In the RETREAT-FRAIL randomized trial of nursing-home residents ≥80 years with systolic BP <130 mm Hg, a protocolized step-down of antihypertensive drugs reduced medication burden and raised systolic BP modestly but did not change all-ca

Geographic Clusters of Late-Life Epilepsy in US Medicare: Sleep and Mobility as Key Contextual Drivers
Neurologyepilepsyolder adults

Geographic Clusters of Late-Life Epilepsy in US Medicare: Sleep and Mobility as Key Contextual Drivers

By MedXY|Nov 25, 2025

A Medicare cohort study mapped incident epilepsy among older adults across the contiguous US and linked high-incidence areas to social and environmental determinants—most strongly insufficient sleep and lack of household vehicle access—sugg

Bivalent RSV pre‑F Vaccine Dramatically Reduces RSV‑Associated Hospitalisations and Chronic‑Disease Exacerbations in Adults Aged 75–79 Years
Infectious Diseasesolder adultsRSV vaccine

Bivalent RSV pre‑F Vaccine Dramatically Reduces RSV‑Associated Hospitalisations and Chronic‑Disease Exacerbations in Adults Aged 75–79 Years

By MedXY|Nov 24, 2025

In a multicentre test‑negative study of 1006 adults aged 75–79 in England, a bivalent RSV pre‑F vaccine reduced RSV‑associated hospitalisation by 82% overall and protected against severe disease and exacerbations of chronic heart and lung d

Brand-Specific Influenza Vaccine Effectiveness in Nordic Older Adults: Insights from the 2024-2025 Season Registry-Based Target Trial Emulation
Clinical Updatesinfluenza vaccineolder adults

Brand-Specific Influenza Vaccine Effectiveness in Nordic Older Adults: Insights from the 2024-2025 Season Registry-Based Target Trial Emulation

By MedXY|Nov 23, 2025

This comprehensive review synthesizes recent evidence on brand-specific influenza vaccine effectiveness (VE) among adults aged ≥65 in Denmark, Finland, and Sweden during the 2024-2025 season, underscoring heterogeneous VE profiles and the c

DAGO2 (daunorubicin+cytarabine+fractionated gemtuzumab) outperforms CPX‑351 in older adults with non‑adverse‑risk AML: insights from NCRI AML18
Hematology-Oncologyacute myeloid leukemiaCPX-351

DAGO2 (daunorubicin+cytarabine+fractionated gemtuzumab) outperforms CPX‑351 in older adults with non‑adverse‑risk AML: insights from NCRI AML18

By MedXY|Nov 15, 2025

In NCRI AML18 (n=439, median age 68), DAGO2 produced higher early CR/MRD‑negative rates and superior 3‑year EFS and OS versus CPX‑351 in older adults without adverse‑risk cytogenetics; survival differences persisted across key subgroups inc

RSV prefusion F bivalent vaccine protects older adults similarly whether or not they have atherosclerotic cardiovascular disease
Cardiologyatherosclerotic cardiovascular diseaseolder adults

RSV prefusion F bivalent vaccine protects older adults similarly whether or not they have atherosclerotic cardiovascular disease

By MedXY|Nov 11, 2025

In a prespecified secondary analysis of the DAN‑RSV randomized trial, the bivalent RSV prefusion F vaccine showed comparable effectiveness against RSV‑related respiratory hospitalizations in adults ≥60 years with and without pre‑existing at

High‑Dose Influenza Vaccine Reduces Hospitalisations in Older Adults
Infectious Diseasesinfluenza vaccineolder adults

High‑Dose Influenza Vaccine Reduces Hospitalisations in Older Adults

By MedXY|Nov 11, 2025

A prespecified pooled analysis of two large randomised pragmatic trials (DANFLU-2 and GALFLU) found high‑dose influenza vaccine reduced hospitalisation for influenza or pneumonia by 8.8% versus standard‑dose in adults ≥65 years, with larger

Each Hour Sitting Counts: Sedentary Time Linked to Lower Intrinsic Capacity and Faster Decline in Older Adults
Internal MedicineIntrinsic Capacityolder adults

Each Hour Sitting Counts: Sedentary Time Linked to Lower Intrinsic Capacity and Faster Decline in Older Adults

By MedXY|Nov 8, 2025

In a prospective Beijing cohort (BLINDSCE), each additional hour of daily sedentary time was associated with a 1.18-point lower baseline intrinsic capacity and a 0.48-point greater decline over 1 year, suggesting sedentary behavior is a mod

Fast versus Slow Compression in Hearing Aids: Hearing Thresholds Predict Preference but Not Speech Outcomes
newshearing aidsolder adults

Fast versus Slow Compression in Hearing Aids: Hearing Thresholds Predict Preference but Not Speech Outcomes

By MedXY|Nov 4, 2025

A randomized crossover trial in older adults found that hearing-loss severity — not cognition or prior hearing-aid experience — predicts preference for slow versus fast compression; speech recognition in quiet and noise was unchanged by com

Preventing Falls in Care Homes: What the 2025 Cochrane Review Now Recommends
newscare homesfalls prevention

Preventing Falls in Care Homes: What the 2025 Cochrane Review Now Recommends

By MedXY|Oct 31, 2025

An evidence-based synthesis of the 2025 Cochrane review on fall-prevention in care facilities: which interventions work, for whom, and how to implement them in practice.

Effectiveness and Safety of RSV Vaccination in US Adults Aged 60 Years or Older: A Comprehensive Evidence Synthesis
Clinical Updatesolder adultsRSV vaccine

Effectiveness and Safety of RSV Vaccination in US Adults Aged 60 Years or Older: A Comprehensive Evidence Synthesis

By MedXY|Oct 31, 2025

RSV vaccines demonstrate substantial effectiveness and acceptable safety profiles in adults aged ≥60, with diminished effectiveness in immunocompromised subgroups and a low, statistically significant increased risk of Guillain-Barré syndrom

Gamified mHealth Strategies Boost Treatment Adherence and Outcomes in Late-Life Depression
newsdepressionmHealth

Gamified mHealth Strategies Boost Treatment Adherence and Outcomes in Late-Life Depression

By MedXY|Oct 27, 2025

Implementing gamification in mobile health psychotherapy markedly improves adherence and reduces depressive symptoms among older adults, offering a promising avenue to address mental health care needs in aging populations.

Empowering Older Adults in Acute Care: Insights on Shared Decision Making for Treatment Escalation Planning
Critical CareAcute careolder adults

Empowering Older Adults in Acute Care: Insights on Shared Decision Making for Treatment Escalation Planning

By MedXY|Oct 20, 2025

This qualitative UK study explores older patients’ perspectives on shared decision making for treatment escalation during acute hospital deterioration, highlighting the need for patient autonomy, education, and adaptable clinical appr

HIV Among Older Adults in Sub-Saharan Africa: Epidemiology, Risks, and Treatment Insights from the AWI-Gen Longitudinal Study
HIV/AIDSantiretroviral therapyepidemiology

HIV Among Older Adults in Sub-Saharan Africa: Epidemiology, Risks, and Treatment Insights from the AWI-Gen Longitudinal Study

By MedXY|Oct 20, 2025

This multicentre longitudinal cohort study reveals significant HIV prevalence and incidence among adults aged 40 and older in sub-Saharan Africa, highlighting age, gender, education, and rural residency as critical factors influencing HIV r

Optimizing Healthy Ageing: The Impact of Physical Activity and Sedentary Behavior on Intrinsic Capacity in Older Adults
Internal MedicineHealthy AgeingIntrinsic Capacity

Optimizing Healthy Ageing: The Impact of Physical Activity and Sedentary Behavior on Intrinsic Capacity in Older Adults

By MedXY|Oct 20, 2025

This prospective Spanish cohort study reveals that moderate-to-vigorous physical activity enhances intrinsic capacity in older adults, while sedentary behavior impairs it, underscoring the role of active lifestyles in promoting healthy agei

Global Trends and Method-Specific Suicide Mortality Among Older Adults: Insights and Projections to 2050
newsglobal healtholder adults

Global Trends and Method-Specific Suicide Mortality Among Older Adults: Insights and Projections to 2050

By MedXY|Oct 20, 2025

A comprehensive study spanning 47 countries reveals changing suicide mortality rates among adults aged 65+, highlighting method-specific risks and projecting future trends amid global population ageing.

Iyengar Yoga and Fall Risk in Older Adults: Unexpected Outcomes from a Rigorous RCT
Neurologyfalls preventionIyengar yoga

Iyengar Yoga and Fall Risk in Older Adults: Unexpected Outcomes from a Rigorous RCT

By MedXY|Oct 20, 2025

A large randomized controlled trial found that an Iyengar yoga-based exercise program increased fall rates among older adults compared to seated relaxation yoga, despite improvements in physical activity and balance confidence, highlighting

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