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This study develops and evaluates prognostic models combining clinical and toxicity information to predict complicated outcomes in ICU patients with acute intoxication, demonstrating the added value of laboratory data over toxicity scores a
A province-wide quality improvement initiative in Ontario implemented a web-based Family Satisfaction in ICU (FS-ICU) survey across adult level 3 ICUs, revealing high satisfaction scores yet highlighting challenges in participation and comp
This comprehensive 10-year ICU study reveals a low prevalence of positive pleural fluid cultures, highlights the significant link to suspected pleural infection, and associates culture positivity with higher 90-day mortality, informing targ
A randomized controlled trial demonstrates that adjunct low-dose ketamine infusion safely decreases opioid use in mechanically ventilated adults without increasing delirium or adverse events, suggesting potential benefits in ICU analgosedat
This study reveals that acute hypoxemic respiratory failure (AHRF) affects half of ICU patients needing respiratory support, with severity linked to worse outcomes. Lung-protective ventilation is common, underscoring the need for standardiz
Early initiation of insulin within two hours for moderate hyperglycemia in ICU patients significantly lowers 30-day mortality compared to delayed or no insulin therapy. This target trial emulation highlights the potential clinical benefit o
Nearly half of psychoactive medications newly prescribed after ICU stays in American adults lack documented diagnostic justification, persisting for up to two years post-hospitalization.
This study highlights varied outcomes of renal replacement therapy in critically ill patients, identifying subgroups who may benefit despite an overall increase in mortality risk.
A single-center study found that 14% of ICU shifts involve aggression or violence against nurses, with recurrence predicted by longer stay and initial aggressive or verbally violent incidents.
RCT evidence shows that restrictive low-use versus liberal high-use physical restraint strategies in mechanically ventilated ICU patients do not differ in days alive without delirium or coma at 14 days.
A pragmatic RCT in an Australian ICU found the ABCDEF bundle did not reduce delirium incidence or duration but improved patients’ ability to perform usual activities at 90 days post-discharge, suggesting possible long-term quality of
This retrospective study demonstrates that open bedside surgical tracheostomy (OBST) is as safe as operating room tracheostomy (ORST), with similar complication rates and a significant cost reduction, supporting OBST as the preferred approa
Qualitative interviews show family PTSD after ICU care is shaped by cumulative stressors across the illness trajectory, highlighting the need for continuous, family-centered communication and support.
MICROINHALO found that automatic cuff pressure control plus subglottic secretion drainage did not reduce tracheal colonization, but it was linked to fewer ventilator-associated pneumonia cases in critically ill intubated patients.
A randomized ICU trial found that sitting spontaneously breathing patients in an armchair for 3 hours improved oxygenation more than staying semi-recumbent in bed, with no serious adverse events.
A multicenter study reveals that culturally and linguistically diverse patients with sepsis had lower in-hospital mortality and shorter ICU stays compared to non-CaLD patients, challenging prior assumptions about healthcare disparities.
A new study highlights significant disparities in delirium detection for Spanish-speaking ICU patients, with usual-care methods missing 72% of cases. Caregiver-administered tools improved detection by 47%, offering a potential solution to l
This review synthesizes findings from the CLEAN-IT trial and historical data to evaluate the impact of chlorhexidine bathing on nosocomial infections, MDR pathogens, and reserve antibiotic consumption in critically ill patients.
A large international trial found that selective decontamination of the digestive tract (SDD) during mechanical ventilation did not reduce hospital mortality but decreased bloodstream infections and antibiotic-resistant organisms, with no c
A nurse-led, interprofessional family support intervention in ICUs modestly increased family satisfaction and significantly improved communication quality and emotional support, addressing a critical gap in family-centered critical care.
