Point-of-care direct potentiometry (DP) and central laboratory indirect potentiometry (IP) are not interchangeable for sodium (Na+) and potassium (K+) measurements in the ICU.
Prospective data reveals a 95% limit of agreement for Na+ of 10.48 mmol/L, which exceeds clinically acceptable thresholds for acute management.
Approximately 10% of electrolyte measurements result in discordant clinical classifications (e.g., normal vs. abnormal) when comparing the two methods.
A significant knowledge gap exists among clinicians, with only 31.1% of surveyed physicians aware of the analytical biases inherent in indirect potentiometry.
Background
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