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This review synthesizes current evidence on pulse versus nonpulse corticosteroid therapy in AE-IPF, contextualizing the SAFER trial findings within prior studies and clinical guidelines to guide management and future research.
A randomized trial shows that a 6-week corticosteroid taper is superior to a 3-week taper for mild immune-related pneumonitis, establishing 6 weeks as the evidence-based standard for short-term treatment success.
A retrospective study found that postoperative prednisone tapering does not reduce delayed facial nerve palsy incidence following acoustic neuroma resection and carries a 10% risk of steroid-related side effects.
This study reveals that central serous chorioretinopathy (CSCR) in patients with immune-mediated disorders exhibits distinct clinical and imaging features, with immune-mediated status linked to poorer visual outcomes and higher recurrence,
A large randomized clinical trial demonstrated that preoperative high-dose corticosteroids do not reduce major postoperative complications in elective digestive cancer surgery, challenging their routine use for perioperative inflammation co
A groundbreaking clinical trial explores whether injecting steroids into the knee’s infrapatellar fat pad can alleviate pain and protect cartilage. While primary pain targets weren’t met, the secondary findings offer a fascinating gli
A groundbreaking study utilizing an AI classifier demonstrates that ARDS inflammatory phenotypes are dynamic and dictate corticosteroid efficacy. While hyperinflammatory patients benefit from steroids, hypoinflammatory patients face increas
A multicentre randomized trial evaluated adjunctive corticosteroids in HIV-negative severe Pneumocystis jirovecii pneumonia, showing a non-significant reduction in 28-day mortality and no safety concerns, and calls for further targeted rese
A randomized trial shows that a 7-day course of oral corticosteroids does not enhance vocal fold remobilization or voice quality in unilateral vocal fold paralysis following thyroid or parathyroid surgery, underscoring the continued importa
A machine learning model using nationwide registry data accurately predicts long-term remission in refractory ulcerative colitis and identifies key prognostic factors such as pseudopolyps.
Dexamethasone is a powerful corticosteroid that requires careful use due to potential harmful drug interactions and side effects. This article highlights crucial precautions and compatibility issues for safe administration.
