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A 9-year-old girl with atopic dermatitis and relapsing nephrotic syndrome achieved sustained remission of both conditions after dupilumab therapy, enabling withdrawal of steroids and tacrolimus.
A pediatric IBD patient’s medication denial due to lack of pediatric FDA labeling prompted physician-led advocacy, resulting in a state law mandating insurance coverage for pediatric medications with adult approval and supporting data
This retrospective case series evaluates the feasibility and 1-year outcomes of using a dedicated Apex Guide with static digital workflow for root membrane preparation and immediate implant placement in 15 patients.
Two hemophilia A patients developed persistent high-titer FVIII inhibitors following AAV-mediated gene therapy with a bioengineered FVIII transgene despite prior extensive FVIII exposure.
This case series examines immunosuppressive management and long-term outcomes in nine Japanese patients undergoing single living-donor lobar lung transplantation from the same donor as prior HSCT, revealing viable reduced immunosuppression
A 34-day-old male infant with serum sodium >200 mmol/L from accidental salt ingestion was successfully treated with peritoneal dialysis, leading to full recovery.
This case explores decision-making support for a man with autism spectrum disorder and prostate cancer, emphasizing tailored communication strategies in serious illness care.
Alopecia areata regrowth may present atypically with acquired curly hair texture, associated with pili torti ultrastructural changes, signifying a unique phenotype requiring clinical recognition.
Two cases of retrograde migration of foreign bodies in the female genital tract were successfully managed with a minimally invasive hysteroscopic technique involving electrosurgical radial incision and Foley catheter dilation, emphasizing s
This report describes two siblings with 46,XY DSD caused by novel biallelic CYB5A variants including a missense and a deep intronic mutation disrupting splicing, expanding knowledge of CYB5A-related disorders.
This retrospective case series evaluates patient-specific pessaries’ success in individuals with prior suboptimal outcomes using standard pessaries for pelvic organ prolapse across Canadian clinical sites.
A 50-year-old woman with metastatic medullary thyroid carcinoma (MTC) lacking RET alterations exhibited a remarkable sustained response to selpercatinib, suggesting potential efficacy beyond RET-mutated cases.
A 24-year-old obese male presents with incidental liver abnormalities; imaging reveals severe steatohepatitis with unusual features prompting detailed diagnostic evaluation and management strategies.
A retrospective series evaluating high-dose oral vitamin D demonstrated rapid improvement and symptom relief in patients with chemotherapy- and radiation-induced skin toxicity without adverse effects, supporting its potential role in oncode
This report discusses four patients with paternally inherited 15q11.2-q13 duplications linked to MKRN3 overexpression, presenting with delayed puberty and varying degrees of hypogonadism.
A 21-year-old woman with Müllerian agenesis underwent a standardized laparoscopic modified Davydov vaginoplasty, achieving an 11 cm neovagina with intact function and no complications at 6-month follow-up.
This report describes the use of dexmedetomidine infusion for sedation in severely agitated adolescents in the ED, highlighting its feasibility as a bridge therapy while awaiting psychiatric care.
A case series delineating a novel EFEMP1 variant, p.Arg140Trp, associated with late-onset peripheral retinal degeneration distinct from classic DHRD/ML, highlighting rod dysfunction precedes structural changes.
Presentation of three neuroendocrine tumor cases illustrating theranostics integration in diagnosis, treatment, and management, highlighting receptor-based imaging and personalized radionuclide therapy.
We present a molecularly confirmed case of CHILD syndrome mimicking Hailey-Hailey disease without classical features, highlighting diagnostic pitfalls and benefits of targeted therapy.
