Tag
Distinct baseline foveal tomographic lesions predict foveal-first versus extrafoveal-first cRORA onset in iAMD. Hyperreflective foci and lesion type inform risk stratification and timing of atrophic progression relevant for emerging dry AMD
This article critically appraises a multicenter study validating the Anti-BNLF2b antibody (P85-Ab) assay, highlighting its superior sensitivity and specificity for early nasopharyngeal carcinoma detection compared to established EBV-based b
This study identifies plasma oxytocin as a superior preoperative biomarker compared to copeptin for early prediction of transient arginine vasopressin deficiency after transsphenoidal pituitary surgery, aiding in risk stratification and pos
This review synthesizes evidence on neurofilament light chain (NFL) as a minimally invasive plasma biomarker predictive of diabetic retinopathy progression and vascular complications, based on integrated intraocular-plasma proteomics and mu
This study reveals that sudden death in heart failure patients often follows gradual clinical decline, challenging the notion that such deaths are always abrupt.
A genome-wide association study identified CNIH4, CCNG1, and RHOJ as genetic modifiers of autosomal dominant Alzheimer’s disease, with associations spanning disease risk, age at onset, fluid biomarkers, and neuroimaging phenotypes.
In a prospective cohort, VWF and FVIII were significantly elevated in chronic graft-versus-host disease, tracked with disease activity, and showed moderate diagnostic performance for early cGvHD.
This review analyzes the landmark SWISS-AF study, demonstrating that serum neurofilament light chain (sNfL), traditionally a marker of neuronal damage, is a potent independent predictor of major vascular events, heart failure, and mortality
A large multicohort and experimental study suggests the cTnI/cTnT ratio is biologically informative, separates acute from chronic myocardial injury, and modestly improves type 1 versus type 2 MI discrimination.
AHRF patients classified as hypoinflammatory are not prognostically uniform. Continuous biomarker-based probabilities reveal substantial mortality heterogeneity, especially below the binary 0.5 threshold, with implications for enrichment st
In a multinational cross-sectional study, serum and CSF neurofilament light chain—unlike S100B—tracked severe acute brain injury in cryptogenic NORSE, rose rapidly over the first 3 weeks, and predicted poor short-term outcome, supporting ur
Women exhibit higher plasma p-tau217 levels and tau aggregation than men in amyloid-positive individuals, suggesting sex-specific pathways in Alzheimer’s disease progression.
A prospective cohort study identifies biomarker signatures for host resistance, disease tolerance, and damage in sepsis, revealing associations with mortality and sepsis subtypes.
Elevated levels of inflammatory and cardiac biomarkers are linked to higher risks of venous thromboembolism and bleeding in cancer patients, according to a post hoc analysis of the AVERT trial.
This review synthesizes recent clinical evidence on the integration of plasma p-tau217 and eMTBR-tau243, highlighting how sequential biomarker testing improves the diagnosis of symptomatic Alzheimer’s disease and predicts longitudinal cogni
A landmark multicohort study of 1,168 individuals reveals that gut microbiome diversity systematically declines across liver disease stages, with specific bacterial markers like Veillonella and functional metabolic shifts predicting disease
A groundbreaking mass spectrometry study analyzing 486 heart failure patients and 98 controls identified over 21,000 unique peptides, revealing 1,924 differentially expressed peptides. The research highlights angiotensin-related peptides, n
This review synthesizes recent evidence identifying MR-proADM as a premier prognostic biomarker in ATTR-CM, demonstrating its ability to outperform traditional natriuretic peptides and enhance existing clinical staging systems.
This review synthesizes findings from a landmark proteomic study identifying 23 plasma proteins associated with VTE risk, highlighting novel pathways in immunity and vascular senescence while exploring causal links through Mendelian Randomi
This large-scale proteomic analysis identifies 15 novel protein markers for venous thromboembolism, offering new insights into the roles of immunity and extracellular matrix regulation in VTE pathogenesis beyond traditional coagulation path
