Synergistic Effects of Metformin and Moderate FODMAP Diet in Improving Postprandial Glycemia and Gut Health in Prediabetes

Highlight

• Combined therapy of metformin and moderate FODMAP diet significantly reduces postprandial glucose excursions and enhances GLP-1 secretion in prediabetic patients.
• Moderate FODMAP intake increases abundance of beneficial butyrate-producing bacteria and reduces systemic inflammation markers.
• No significant increase in gastrointestinal side effects observed compared to low FODMAP intake during metformin therapy.
• Baseline abundance of Dorea formicigenerans may predict metformin intolerance, highlighting gut microbiota’s role in drug response.

Study Background and Disease Burden