Statin Therapy in Older Adults with Chronic Kidney Disease: Primary Prevention of Cardiovascular Disease and Safety Profile in Hypercholesterolemic Patients

Highlight

This large territory-wide cohort study using target trial emulation provides strong evidence that statin therapy in hypercholesterolemic older adults with chronic kidney disease (CKD) aged 75 and above is associated with significant reduction in overall cardiovascular disease incidence and all-cause mortality. The study also confirms the safety of statin use in this population, showing no significant increase in myopathies or liver dysfunction. These benefits persist even in very old adults aged 85 years and older.

Study Background