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Sex- and Age-Specific Genetic Risk Across Dilated and Arrhythmogenic Cardiomyopathy: Insights From the SHaRe Registry
Cardiologycardiomyopathygenetics

Sex- and Age-Specific Genetic Risk Across Dilated and Arrhythmogenic Cardiomyopathy: Insights From the SHaRe Registry

By MedXY|May 25, 2026

A large registry study found that genetic cardiomyopathy risk varies by sex, age, and gene. TTN truncating variants were more common and earlier in males, while DSP and non-TTN sarcomeric variants were more common in females.

Pediatric Hypertrophic Cardiomyopathy: The High-Risk Profile of Massive Left Ventricular Hypertrophy
CardiologyHypertrophic Cardiomyopathyleft ventricular hypertrophy
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Pediatric Hypertrophic Cardiomyopathy: The High-Risk Profile of Massive Left Ventricular Hypertrophy

By MedXY|Apr 24, 2026

A multiregistry analysis reveals that massive LVH in pediatric HCM is linked to early diagnosis, sarcomeric mutations, and heightened risks of arrhythmias, heart failure, and mortality. Nearly 25% of patients show significant LVH regression

A New Standard for Pediatric Vocal Fold Immobility After Cardiac Surgery: Improving Outcomes Through Injection Laryngoplasty
CardiologyCardiothoracic SurgeryDysphagia

A New Standard for Pediatric Vocal Fold Immobility After Cardiac Surgery: Improving Outcomes Through Injection Laryngoplasty

By MedXY|Mar 13, 2026

Recent research highlights a standardized multidisciplinary protocol for managing unilateral vocal fold immobility in infants after cardiothoracic surgery, showing that injection laryngoplasty significantly improves oral feeding advancement

Long-Term Reality of Single-Ventricle Reconstruction: Shunt Choice, Tricuspid Regurgitation, and the Burden of Global Morbidity
CardiologyHypoplastic Left Heart Syndromepediatric cardiology

Long-Term Reality of Single-Ventricle Reconstruction: Shunt Choice, Tricuspid Regurgitation, and the Burden of Global Morbidity

By MedXY|Mar 11, 2026

A 16-year follow-up of the SVR trial reveals that while shunt types show similar long-term outcomes overall, pre-existing tricuspid regurgitation significantly impacts survival with RVPAS, amid a staggering 87% rate of major morbidity.

Twice-Yearly Inclisiran Transforms LDL-C Management in Adolescents with HeFH: Insights from ORION-16
CardiologyFamilial HypercholesterolaemiaInclisiran

Twice-Yearly Inclisiran Transforms LDL-C Management in Adolescents with HeFH: Insights from ORION-16

By MedXY|Mar 10, 2026

The ORION-16 trial demonstrates that inclisiran, a twice-yearly siRNA therapy, significantly and safely reduces LDL cholesterol in adolescents with heterozygous familial hypercholesterolaemia, offering a promising solution for long-term adh

Minima Stent System Proves Safe and Effective for Vascular Stenosis in Infants: Results of the Multicenter Pivotal Trial
Cardiologycongenital heart diseasepediatric cardiology

Minima Stent System Proves Safe and Effective for Vascular Stenosis in Infants: Results of the Multicenter Pivotal Trial

By MedXY|Jan 18, 2026

A multicenter trial confirms the Minima Stent’s efficacy in treating pulmonary artery stenosis and aortic coarctation in infants. With a 97.6% success rate and growth-accommodating design, it addresses a critical unmet need in pediatr

Prognostic Value of 2D Speckle Tracking Echocardiography in Multisystem Inflammatory Syndrome in Children: Insights From the MUSIC Study
Cardiologypediatric cardiology

Prognostic Value of 2D Speckle Tracking Echocardiography in Multisystem Inflammatory Syndrome in Children: Insights From the MUSIC Study

By MedXY|Oct 6, 2025

This multicenter study highlights the utility of 2D speckle tracking echocardiography for early detection and prognostication of left ventricular dysfunction in MIS-C, informing cardiovascular risk and management.

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