The 2025 Lancet Commission’s “clinical obesity” definition incorporates measures of adiposity and organ dysfunction, contrasting with traditional BMI-only diagnosis.
Applying this definition in 56 low- and middle-income countries (LMICs) resulted in over 50% reductions in obesity prevalence in some regions.
The new framework improves disease specificity but raises questions about missed opportunities for primary prevention and surveillance challenges.
Global implementation faces barriers related to data availability and potential undercounts in resource-limited settings.
Background
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