Large prospective data show that incident myocardial infarction (MI) doubles the risk of developing late-onset epilepsy (LOE) in stroke-free older adults.
LOE similarly signals elevated risk for subsequent MI and nonstroke vascular death, indicating bidirectional associations suggestive of systemic vascular pathology.
Findings support considering LOE as a vascular risk equivalent, highlighting the need for intensified vascular risk factor control and interdisciplinary clinical attention.
Further research is needed to validate these findings in diverse populations and elucidate underlying pathophysiological mechanisms.
Background
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