Myocardial Fibrosis and Reverse Remodeling After Valve Replacement in Chronic Aortic Regurgitation: Advances and Clinical Implications

MedXY Editorial Team•Aug 28, 2026•Cardiology

Advanced cardiac magnetic resonance (CMR) techniques identify both focal and diffuse myocardial fibrosis in chronic aortic regurgitation (AR) and predict post-AVR remodeling outcomes.
AVR leads to significant left ventricular reverse remodeling characterized by reductions in LV end-diastolic volume (LVEDV), LV mass, and indexed extracellular volume, with cellular regression outpacing matrix regression.
Focal myocardial scars quantified by late gadolinium enhancement (LGE) remain stable post-AVR and are independently associated with incomplete reverse remodeling.
Despite structural improvements, objective functional capacity measured by maximal oxygen consumption may not substantially improve at early follow-up after AVR.

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This article was created using several editorial tools, including AI, as part of the process. Human editors reviewed this content before publication.

Advanced cardiac magnetic resonance (CMR) techniques identify both focal and diffuse myocardial fibrosis in chronic aortic regurgitation (AR) and predict post-AVR remodeling outcomes.
AVR leads to significant left ventricular reverse remodeling characterized by reductions in LV end-diastolic volume (LVEDV), LV mass, and indexed extracellular volume, with cellular regression outpacing matrix regression.
Focal myocardial scars quantified by late gadolinium enhancement (LGE) remain stable post-AVR and are independently associated with incomplete reverse remodeling.
Despite structural improvements, objective functional capacity measured by maximal oxygen consumption may not substantially improve at early follow-up after AVR.