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This review synthesizes current evidence on myocardial fibrosis and ventricular remodeling after AVR in chronic AR, highlighting imaging biomarkers, remodeling patterns, and functional outcomes relevant to clinical practice.
This study identifies RUNX1-mediated endothelial-to-mesenchymal transition as a key driver of myocardial fibrosis and remodeling in LMNA cardiomyopathy, highlighting potential therapeutic avenues targeting endothelial RUNX1 signaling.
The EVOLVED trial reveals that higher myocardial fibrosis burden associates with adverse events in asymptomatic severe aortic stenosis patients, yet early intervention benefits appear nuanced—showing promise for reducing hospitalizations in
A prospective case-control study demonstrates that myocardial fibroblast activation persists in heart failure patients and follows distinct spatial patterns depending on etiology. Using [68Ga]FAPI-46 PET/MRI, researchers found that higher b
