Metabolic Syndrome Increases Parkinson’s Disease Risk: Implications for Clinical Practice and Prevention

Highlight

• Individuals with metabolic syndrome have a 39% increased risk of developing Parkinson’s disease (PD) compared to those without the syndrome.
• Genetic predisposition amplifies PD risk in patients with metabolic syndrome, with nearly double the risk observed in high-risk genotypes.
• The PD risk increases in a dose-dependent manner according to the number of metabolic risk factors present.
• Findings emphasize the potential of lifestyle interventions targeting metabolic health to reduce PD risk, even for genetically predisposed individuals.

Study Background and Disease Burden