Maternal Tdap-IPV vaccination significantly increases nasal anti-pertussis toxin and anti-B. pertussis IgG in infants at 8 weeks of age, demonstrating effective transplacental transfer to the upper airway mucosa.
Infants receiving the whole-cell pertussis (DTwP) primary vaccine series developed significantly higher mucosal IgG and broader nasal T-cell cytokine responses compared to those receiving the acellular (DTaP) vaccine.
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