Kidney Tubular Biomarkers as Predictors of Mortality and Heart Failure Readmission in Acute Heart Failure Patients

Highlight

– Kidney tubular injury and dysfunction biomarkers, including IGFBP-7, KIM-1, MCP-1, and CCL-14, independently predict death and heart failure readmission in acute heart failure.
– These tubular biomarkers provide prognostic information beyond traditional kidney glomerular markers and cardiac biomarkers.
– IGFBP-7 specifically correlates with risk of death, whereas MCP-1 and CCL-14 associate with heart failure readmission.
– This study supports inclusion of tubular health assessment for risk stratification in acute heart failure management.

Study Background and Disease Burden