Gut Microbiota as a Key Determinant of Quality of Life Impairment in Inflammatory Bowel Disease

Highlight

• Health-related quality of life (HRQOL) is significantly reduced in IBD patients despite clinical remission.
• Gut microbiota composition demonstrates stronger associations with impaired HRQOL than traditional disease activity indices.
• Diminished alpha diversity and distinct beta diversity of oral and fecal microbiota mark patients with impaired HRQOL.
• Targeted microbial manipulation could represent a novel therapeutic avenue to enhance HRQOL beyond immunosuppressive therapies.

Study Background