Evaluating a Proactive E-Health Intervention for Co-occurring At-Risk Alcohol Use and Depressive Symptoms: Adherence, Reach, and Two-Year Outcomes

Highlight

• A proactive e-health intervention reaches 51% of eligible patients with co-occurring at-risk alcohol use and depressive symptoms.
• High adherence observed with 73% of intervention participants receiving all components over six months.
• Small, statistically non-significant reductions in a composite alcohol-depression measure noted at 6 and 12 months, with no effect at 24 months.
• Potential greater benefit for participants without baseline major depression suggests effect modification.

Study Background and Disease Burden