Highlight
• Patients with hidradenitis suppurativa (HS) have a significantly higher risk of developing new-onset depression and anxiety than the general population.
• This elevated mental health risk persists regardless of HS treatment modality or severity based on hospitalizations for surgical procedures.
• No increased risk for recurrent depression or anxiety episodes was found among patients with a history of these conditions.
• Findings emphasize the importance of psychiatric screening and intervention for all HS patients, not only those with severe disease.
