Early Aspirin Withdrawal after PCI in Low‑Risk MI: P2Y12‑Inhibitor Monotherapy Noninferior and Significantly Less Bleeding

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– In TARGET‑FIRST (N=1,942 randomized), early discontinuation of aspirin after 1 month of uneventful DAPT in low‑risk acute MI patients was noninferior to continuing DAPT for the composite of death, MI, stent thrombosis, stroke, or major bleeding at 11 months.

– P2Y12‑inhibitor monotherapy reduced clinically relevant bleeding (BARC 2, 3, or 5) from 5.6% to 2.6% (HR 0.46; 95% CI, 0.29–0.75; P=0.002) without an increase in stent thrombosis or serious adverse events.