Cryopreserved Versus Liquid-Stored Platelets in Surgical Bleeding: Insights from the CLIP-II Randomized Noninferiority Trial

Highlights

• The CLIP-II trial is the first large randomized noninferiority study comparing cryopreserved platelets with conventional liquid-stored platelets for surgical bleeding control.
• Cryopreserved platelets, despite a significantly longer shelf-life, did not demonstrate noninferior hemostatic effectiveness compared to liquid-stored platelets at 24 hours post-ICU admission.
• Transfusion of cryopreserved platelets was associated with increased perioperative blood loss and greater need for additional blood product transfusions.
• Safety outcomes were comparable, but patients receiving cryopreserved platelets had longer durations of ventilation and hospital stays.

Background