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A systematic review and meta-analysis of 26 RCTs reveals that prophylactic tranexamic acid (TXA) significantly reduces blood loss and transfusion needs in general surgery. While safety profiles are favorable, procedural nuances—particularly
The CLIP-II trial evaluated dimethyl sulfoxide-cryopreserved platelets with extended shelf-life against conventional liquid-stored platelets in cardiac surgery bleeding, finding noninferiority was not established and cryopreserved platelets
The FiiRST-2 trial found no superiority of clotting factor concentrates over frozen plasma for initial resuscitation in severely bleeding trauma patients, with similar transfusion needs and safety outcomes.
Recent randomized trials compare suture/plug-based versus suture-only and pure plug-based vascular closure techniques after TF-TAVI, revealing differences in complication rates and hemostasis times.
