Highlight
– Intensive lifestyle interventions involving weight loss plus exercise preserve distal tibia cortical thickness and hip bone strength in older adults with obesity.
– Despite significant weight loss (~11.6 kg over 12 months), no deleterious effects on bone quality were observed compared to usual lifestyle advice.
– The LIMB-Q trial used advanced imaging methods, including high-resolution peripheral quantitative CT and finite element analysis, to assess cortical bone thickness and biomechanical strength.
– Safety profile was acceptable, with few musculoskeletal adverse events reported during exercise training.
