Highlights
– The PROMISE trial is the first randomized study to compare an aetiology-guided (stratified) treatment strategy against usual care in patients with myocardial infarction with non‑obstructive coronary arteries (MINOCA).
– At 12 months, the stratified strategy produced a clinically and statistically significant improvement in angina-related health status (Seattle Angina Questionnaire summary score difference +9.38, 95% CI 6.81–11.95; p<0.001).
