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This article reviews the ViVA trial assessing vericiguat, an sGC stimulator, in angina patients with coronary vasospasm but no obstructive coronary artery disease. The study found no significant improvement in vasodilator function or angina
Surgical unroofing significantly improves long-term symptoms and quality of life in patients with symptomatic myocardial bridge and non-obstructive coronary arteries refractory to medical therapy.
ORBITA-FIRE shows that angina occurs at much lower, individualized FFR and RFR thresholds than standard ischemia cutoffs, and these thresholds rise with exercise intensity.
ORBITA-FIRE study reveals personalized physiological thresholds for angina that are lower than current diagnostic standards. These thresholds vary during exercise and predict PCI treatment success, challenging universal ischemia-based guide
A pooled analysis of EUROCTO and DECISION-CTO trials found PCI significantly improved quality of life, angina frequency, and SAQ scores compared to medical therapy for patients with chronic total coronary occlusions, with no increased risk
A nationwide Danish cohort study reveals that women with angina or non-specific chest pain and no obstructive coronary artery disease face significantly higher rates of cardiac readmissions and primary care consultations compared to asympto
The PROMISE randomized trial shows that comprehensive, aetiology‑guided management of MINOCA significantly improves angina-related health status at 12 months versus standard care, supporting systematic diagnostic evaluation and individualiz
The ILIAS ANOCA randomized trial shows that routine invasive coronary function testing (CFT) during angiography in patients with angina and non‑obstructive coronary arteries (ANOCA) is feasible, safe, yields a high diagnostic rate of vasomo
A multicenter randomized trial shows stress CMR myocardial perfusion mapping with endotype-directed therapy reclassified diagnosis in 53% of patients with unobstructed coronaries and produced a large, clinically meaningful 21-point improvem
