Highlights
– Adjunctive ultrasonography (US) combined with mammography (MG) reduced the cumulative incidence of advanced breast cancer (Stage 2 or higher) by 17% compared to MG alone (HR 0.83, p=0.026).
– The divergence in advanced cancer incidence between the two groups became significant after 48 months, suggesting a long-term benefit from early detection.
– This study provides robust evidence for the integration of US into screening programs for women aged 40-49, particularly in Asian populations where dense breast tissue is common.
