Highlights
In this prospective cohort of patients with lacunar or mild nonlacunar stroke, large-artery stenosis of 50% or greater was associated with lower odds of lacunar stroke and showed no meaningful relationship with cerebral small-vessel disease markers or incident infarcts over 1 year.
By contrast, basilar artery dolichoectasia and wider intracranial arteries were strongly associated with lacunar stroke, greater baseline cSVD burden, more incident infarcts, and progression of white matter hyperintensities.
