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This study identifies glycine and specific lipid cholesterol proportions as metabolomic markers causally linked to lacunar stroke subtypes, enhancing understanding of cerebral small vessel disease pathogenesis and potential biomarkers.
In a prospective mild stroke cohort, cranial arterial stenosis was not linked to cSVD, whereas basilar dolichoectasia and wider intracranial arteries were strongly associated with lacunar stroke, higher cSVD burden, incident infarcts, and w
In a prospective mild stroke cohort, cranial arterial dolichoectasia and larger intracranial arterial diameters were linked to lacunar stroke, cSVD burden, and incident infarcts, whereas large-artery stenosis was not.
This longitudinal study reveals persistent cognitive, physical, and vascular challenges up to 9 years after minor lacunar or cortical ischemic stroke, emphasizing different risks and recovery patterns by stroke subtype.