Unraveling Chronic Stress: The Role of Gut Dysbiosis and Vitamin B6 Metabolism in Stress-Related Brain Disorders Independent of Cortisol
Highlight
- Chronic stress induces gut dysbiosis, disrupting vitamin B6 metabolism and triggering abnormal behaviors independent of HPA axis activation.
- Microbiota transplantation from stressed rats transfers core phenotypes including inflammation and behavioral abnormalities to normal rats.
- Vitamin B6 supplementation and probiotics mitigate stress-induced behavioral and inflammatory disturbances without altering corticosterone levels.
- Inflammatory pathways involving caspase 11 and caspase 1 mediate peripheral and neuroinflammation in chronic stress, presenting new therapeutic targets.
Study Background and Disease Burden
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This article was created using several editorial tools, including AI, as part of the process. Human editors reviewed this content before publication.