DMT management during pregnancy increases relapse risk in women with multiple sclerosis, especially with natalizumab interruption or prior fingolimod use.
Anti-CD20 monoclonal antibody therapy administered prior to conception offers the greatest protection against pregnancy- and postpartum-related relapses.
Natalizumab with short interruption is more effective than interferon β or glatiramer acetate for relapse prevention during pregnancy.
Real-world registry data provide robust comparative effectiveness for DMT strategies across pregnancy stages.
Study Background and Disease Burden
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This article was created using several editorial tools, including AI, as part of the process. Human editors reviewed this content before publication.
