TAVI Superiority in Women with Aortic Stenosis: New Evidence from the DEDICATE-DZHK6 Trial

Highlights

The sex-specific analysis of the DEDICATE-DZHK6 trial provides critical insights into the management of aortic stenosis in low- to intermediate-risk patients. Key highlights include:

• TAVI demonstrated significantly lower rates of all-cause death or stroke at one year compared to SAVR in both women and men.
• Women assigned to SAVR experienced a notably higher risk of stroke (6.2%) compared to those receiving TAVI (2.6%).
• Despite being older and having higher surgical risk scores at baseline, women derived a substantial survival benefit from the transcatheter approach.
• The trial reaffirms TAVI as a preferred or equally viable strategy for both sexes in the low-to-intermediate risk category, challenging traditional surgical-first paradigms.