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This Shanghai cohort study reveals that higher parental vitamin B12 and maternal postconception RBC folate levels associate with significantly lower birth defect prevalences, highlighting novel nutritional targets beyond maternal folic acid
Biallelic loss-of-function mutations in BPNT1 are identified as a new genetic cause of vitamin B12-dependent megaloblastic anemia, linked to disrupted ribosome biogenesis and impaired ileal vitamin B12 absorption in mouse models.
The ALICE international cohort found 31.7% prevalence of preoperative anaemia in major surgery patients; iron deficiency accounted for 55% of confirmed causes, with notable contributions from vitamin B12 and folate deficiencies. Broader pre
A 200‑patient cross‑sectional study found metformin use tripled the odds of vitamin B12 deficiency without affecting vitamins A, B1, B6, B9, C or E, highlighting the need for targeted B12 monitoring in long‑term metformin therapy.
Elevated vitamin B12 levels from mid- to late life correlate with reduced rates of cognitive decline across language, memory, and executive function domains, independent of folate status, highlighting potential preventative strategies again
A comprehensive meta-analysis reveals that elevated serum vitamin B12 levels do not conclusively predict increased all-cause mortality risk in adults, highlighting the complexity and heterogeneity of existing research.
Vitamin B12, an inexpensive supplement, plays a crucial role in health, especially for the elderly, by potentially improving anemia, cognitive decline, cardiovascular risks, and nerve health.
Vitamin B12 deficiency can lead to serious health issues, including anemia and cognitive decline. Learn who is at risk and how to manage this deficiency.