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Evaluating the Impact of a Prehospital 1-Hour Resuscitation Bundle on Septic Shock Mortality: Insights from the SAMU Save Sepsis Study
Allergy & Immunologyresuscitation bundleprehospital care

Evaluating the Impact of a Prehospital 1-Hour Resuscitation Bundle on Septic Shock Mortality: Insights from the SAMU Save Sepsis Study

By MedXY|Aug 11, 2026

A multicenter randomized trial found that initiating a 1-hour resuscitation bundle including early antibiotics, fluids, vasopressors, and hydrocortisone in the prehospital setting did not significantly reduce 28-day mortality in adults with

Combining Tissue Hypoperfusion Markers with Vasopressor Dose Enhances Mortality Risk Stratification in Refractory Septic Shock
Critical Care
refractory shock
risk stratification

Combining Tissue Hypoperfusion Markers with Vasopressor Dose Enhances Mortality Risk Stratification in Refractory Septic Shock

By MedXY|Jul 21, 2026

Persistent tissue hypoperfusion alongside vasopressor dosing improves early risk stratification in refractory septic shock, identifying patients with markedly increased 28-day mortality beyond vasopressor dose alone, as shown in a secondary

Phenylephrine Versus Norepinephrine in Acute Abdomen Surgery: Similar Clinical Outcomes but Different Early Renin Responses — Implications for Perioperative Hemodynamic Care
Anesthesiologyvasopressors

Phenylephrine Versus Norepinephrine in Acute Abdomen Surgery: Similar Clinical Outcomes but Different Early Renin Responses — Implications for Perioperative Hemodynamic Care

By MedXY|Dec 10, 2025

A randomized trial in 156 emergency acute-abdomen patients found phenylephrine and norepinephrine produced similar postoperative RAAS changes and complication rates; norepinephrine produced an early renin rise, while high preoperative renin

Choice of Vasopressor in Septic Shock: Does It Change Kidney Outcomes? A Critical Appraisal of the Evidence
Critical Careacute kidney injuryrenal outcomes

Choice of Vasopressor in Septic Shock: Does It Change Kidney Outcomes? A Critical Appraisal of the Evidence

By MedXY|Nov 7, 2025

A systematic review of 17 randomized trials (n=4,259) found no consistent renoprotective effect from any vasopressor in septic shock. Heterogeneous definitions, underpowered studies, and reliance on RRT limit conclusions; standardized renal

Adjunctive Terlipressin in Refractory Septic Shock: Lowers High-Dose Catecholamine Need at 6 Hours but No Mortality Benefit
Critical Carecritical careseptic shock

Adjunctive Terlipressin in Refractory Septic Shock: Lowers High-Dose Catecholamine Need at 6 Hours but No Mortality Benefit

By MedXY|Nov 7, 2025

In a double-blind RCT of 130 patients with refractory septic shock, terlipressin increased the proportion achieving MAP ≥65 mmHg with low catecholamine exposure at 6 hours versus placebo but did not change 28-day mortality; digital ischemia

Preventing Post‑Induction Hypotension With Low‑Dose Norepinephrine Reduces Postoperative Complications After Major Abdominal Surgery
AnesthesiologyIntraoperative HypotensionMajor Abdominal Surgery

Preventing Post‑Induction Hypotension With Low‑Dose Norepinephrine Reduces Postoperative Complications After Major Abdominal Surgery

By MedXY|Nov 6, 2025

A single‑center RCT found that starting a titrated norepinephrine infusion at anesthesia induction reduced intraoperative hypotension and lowered 30‑day medico‑surgical complications compared with reactive ephedrine boluses in high‑risk abd

Reassessing the Safety of Peripheral Vasopressor Use in Early Sepsis: Evidence from a Large Prospective Cohort Study
Critical Caresafetysepsis

Reassessing the Safety of Peripheral Vasopressor Use in Early Sepsis: Evidence from a Large Prospective Cohort Study

By MedXY|Oct 27, 2025

This study evaluates factors influencing vasopressor route choice in sepsis and demonstrates low complication rates associated with peripheral administration, supporting its safety in early resuscitation.

Postoperative Vasopressor Use After Noncardiac Surgery: Patterns, Outcomes, and Clinical Implications from a Global Observational Study
AnesthesiologyMortalitynoncardiac surgery

Postoperative Vasopressor Use After Noncardiac Surgery: Patterns, Outcomes, and Clinical Implications from a Global Observational Study

By MedXY|Oct 27, 2025

An international study reveals that postoperative vasopressor infusions after noncardiac surgery vary widely across hospitals and are linked to higher mortality and complications, highlighting the need for optimized management strategies.

Low-Dose Hydrocortisone in Cirrhotic Patients With Septic Shock: A Double-Blind Randomised Placebo-Controlled Trial
Clinical Updatescirrhosishydrocortisone

Low-Dose Hydrocortisone in Cirrhotic Patients With Septic Shock: A Double-Blind Randomised Placebo-Controlled Trial

By MedXY|Oct 1, 2025

This trial evaluated low-dose hydrocortisone in cirrhotic patients with septic shock, finding no improvement in 28-day mortality or shock resolution compared to placebo.

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