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Parenteral vs Oral Glucocorticoids in Early Rheumatoid Arthritis: Impact on Steroid Discontinuation and Therapy Escalation at One Year
newsrheumatoid arthritisparenteral administration

Parenteral vs Oral Glucocorticoids in Early Rheumatoid Arthritis: Impact on Steroid Discontinuation and Therapy Escalation at One Year

By MedXY|Sep 4, 2026

This study assesses whether the administration route of glucocorticoids in early rheumatoid arthritis influences continued steroid use and advanced therapy initiation at one year.

Decoding Systemic Inflammation in Long COVID and Autoimmune Diseases: The Role of Intestinal Flagellin and the TLR5-IL-15-ARA Axis
GastroenterologyIL-15
Systemic Inflammation

Decoding Systemic Inflammation in Long COVID and Autoimmune Diseases: The Role of Intestinal Flagellin and the TLR5-IL-15-ARA Axis

By MedXY|Aug 22, 2026

This article explores how intestinal flagellin drives systemic inflammation via the TLR5-IL-15-ARA pathway in long COVID, rheumatoid arthritis, ankylosing spondylitis, and IBD, highlighting potential therapeutic targets and biomarkers.

Unraveling the Gut-Lung Axis: Intestinal Flagellin as a Driver of Multisystem Inflammation via the TLR5-IL-15-ARA Pathway
GastroenterologyIL-15Systemic Inflammation

Unraveling the Gut-Lung Axis: Intestinal Flagellin as a Driver of Multisystem Inflammation via the TLR5-IL-15-ARA Pathway

By MedXY|Aug 21, 2026

Flagellated gut bacteria activate TLR5 on neutrophils, triggering IL-15 release and macrophage arachidonic acid production, driving systemic inflammation in long COVID, rheumatoid arthritis, ankylosing spondylitis, and IBD.

Early B-Cell Depletion Patterns Predict Long-Term Rituximab Outcomes and Refractory Disease in Rheumatoid Arthritis
newsRituximabB細胞枯渇

Early B-Cell Depletion Patterns Predict Long-Term Rituximab Outcomes and Refractory Disease in Rheumatoid Arthritis

By MedXY|Aug 20, 2026

High-sensitivity flow cytometry reveals that early plasmablast depletion predicts 5-year rituximab response in rheumatoid arthritis, while incomplete memory B-cell depletion signals poly-refractory disease.

Lung Transplantation in Rheumatoid Arthritis-Associated Interstitial Lung Disease: Identifying Risk Factors and Survival Outcomes in a Universal Healthcare Context
newslung transplantationComorbidities

Lung Transplantation in Rheumatoid Arthritis-Associated Interstitial Lung Disease: Identifying Risk Factors and Survival Outcomes in a Universal Healthcare Context

By MedXY|Aug 17, 2026

This study examines lung transplantation patterns, associated risk factors, and post-transplant survival among rheumatoid arthritis-related interstitial lung disease patients in Ontario, revealing key clinical insights under a universal hea

Low-dose Blinatumomab Therapy in Multidrug-Resistant Rheumatoid Arthritis: A Case Series Analysis
Hematology-OncologyT-cell Engagermultidrug resistance

Low-dose Blinatumomab Therapy in Multidrug-Resistant Rheumatoid Arthritis: A Case Series Analysis

By MedXY|Aug 17, 2026

A case series assessing the safety and efficacy of low-dose blinatumomab in 15 patients with multidrug-resistant rheumatoid arthritis showed synovial B-cell depletion, reduced disease activity, and improved response to previously ineffectiv

Internal MedicineJAK inhibitorsmuscle wasting

Tofacitinib Reverses Muscle Loss in Rheumatoid Arthritis: Insights from the RAMUS Trial

By MedXY|Dec 19, 2025

The RAMUS study demonstrates that the JAK inhibitor tofacitinib significantly increases lower limb muscle volume in patients with rheumatoid arthritis, offering a potential explanation for associated creatinine elevations and a new therapeu

Internal MedicineJAK inhibitorsmuscle wasting

Tofacitinib and Muscle Volume: A Potential Paradigm Shift in Managing Rheumatoid Cachexia

By MedXY|Dec 19, 2025

The RAMUS study demonstrates that tofacitinib significantly increases lower limb muscle volume in rheumatoid arthritis patients, potentially explaining associated creatinine elevations and offering a new therapeutic avenue for combating mus

Unveiling Early Rheumatoid Arthritis-Associated Interstitial Lung Disease: Risk Factors and Validation of Screening Approaches in the SAIL-RA Cohort
newsearly diagnosisBệnh phổi mô kẽ

Unveiling Early Rheumatoid Arthritis-Associated Interstitial Lung Disease: Risk Factors and Validation of Screening Approaches in the SAIL-RA Cohort

By MedXY|Oct 19, 2025

This article examines the prevalence, risk factors, and diagnostic screening strategies for rheumatoid arthritis-associated interstitial lung disease (RA-ILD) in early rheumatoid arthritis, highlighting age and disease activity as key predi

Diagnosing and Managing Methotrexate-Induced Osteopathy in Rheumatologic Practice
newsmethotrexateosteopathy

Diagnosing and Managing Methotrexate-Induced Osteopathy in Rheumatologic Practice

By MedXY|Oct 9, 2025

Methotrexate-induced osteopathy, predominantly affecting postmenopausal women with rheumatoid or psoriatic arthritis, presents as stress fractures in the lower limbs. Early MRI or bone scintigraphy aids diagnosis, and discontinuing methotre

Distinguishing Low-Grade MRI Inflammation in Rheumatoid Arthritis: Insights from Healthy Controls and At-Risk Populations
newsrheumatoid arthritis

Distinguishing Low-Grade MRI Inflammation in Rheumatoid Arthritis: Insights from Healthy Controls and At-Risk Populations

By MedXY|Oct 5, 2025

This cohort study reveals that low-grade MRI-detected inflammation in hand, wrist, and forefoot joints is common in healthy individuals and at-risk groups, underscoring challenges in distinguishing rheumatoid arthritis-specific inflammation

Dual JAK and ROCK Inhibition with CPL’116: A Promising Advance for Methotrexate-Refractory Rheumatoid Arthritis
Allergy & Immunologyclinical trialJAK inhibitor

Dual JAK and ROCK Inhibition with CPL’116: A Promising Advance for Methotrexate-Refractory Rheumatoid Arthritis

By MedXY|Oct 5, 2025

CPL’116, a novel dual JAK and ROCK inhibitor, demonstrates dose-dependent efficacy and a favorable safety profile in rheumatoid arthritis patients inadequately responsive to methotrexate, without the typical lipid or creatine kinase a

Intermittent Fasting in Overweight and Obese Postmenopausal Women with Rheumatoid Arthritis: Insights from a Randomized Controlled Trial
Clinical Updatesclinical trialintermittent fasting

Intermittent Fasting in Overweight and Obese Postmenopausal Women with Rheumatoid Arthritis: Insights from a Randomized Controlled Trial

By MedXY|Oct 2, 2025

A recent RCT suggests intermittent fasting may improve physical function and disease activity in overweight and obese postmenopausal women with RA, but shows no significant effect on inflammation or oxidative stress markers.

Functional MRI Brain Activation as a Predictor of Response to TNF Inhibition in Rheumatoid Arthritis: Insights from the PreCePra Phase 3 Study
Clinical Updatesbiomarkersrheumatoid arthritis

Functional MRI Brain Activation as a Predictor of Response to TNF Inhibition in Rheumatoid Arthritis: Insights from the PreCePra Phase 3 Study

By MedXY|Oct 1, 2025

A phase 3 trial indicates that fMRI-detected CNS pain activation may predict which rheumatoid arthritis patients respond best to TNF inhibitor therapy.

FDA Approves First Vagus Nerve Stimulation Device for Rheumatoid Arthritis: New Horizons for Refractory Disease
Clinical Updatesrheumatoid arthritisvagus nerve stimulation

FDA Approves First Vagus Nerve Stimulation Device for Rheumatoid Arthritis: New Horizons for Refractory Disease

By MedXY|Sep 30, 2025

The FDA has approved the first vagus nerve stimulation device for moderate-to-severe rheumatoid arthritis unresponsive to biologic or synthetic DMARDs, offering a novel neuromodulatory approach to disease management.

Personal and Household Pesticide Exposure Linked to Increased Risk of Rheumatoid Arthritis in Female Farm Spouses
Clinical Updatesrheumatoid arthritis

Personal and Household Pesticide Exposure Linked to Increased Risk of Rheumatoid Arthritis in Female Farm Spouses

By MedXY|Sep 30, 2025

New evidence links direct and indirect exposure to specific agricultural pesticides with increased risk of incident rheumatoid arthritis among female spouses of licensed pesticide applicators.

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