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A 10-year follow-up of early rheumatoid arthritis patients treated with a treat-to-target strategy shows sustained remission leads to lasting clinical, structural, and functional benefits, supporting current treatment guidelines.
This article explores distinct immune cell activations in ACPA-positive individuals progressing to rheumatoid arthritis, emphasizing type I interferon activity prior to ultrasound-detectable synovitis and subsequent inflammatory shifts mark
A real-world Japanese study finds comparable 24-month treatment persistence between reduced and standard dosing of JAK inhibitors in rheumatoid arthritis patients with preserved renal function, with dose considerations influenced by poor pr
Enhanced lipolysis in synovial fibroblasts marks early pathogenic changes in individuals at risk for rheumatoid arthritis, indicating metabolic shifts precede clinical disease onset.
This study reveals that exposure to fine particulate matter (PM2.5) significantly increases disease activity and flare risk in rheumatoid arthritis patients, highlighting the importance of air quality in disease management.
MRI-detected hand tenosynovitis and ultrasound-detected bone erosions independently and jointly predict progression to inflammatory arthritis in anti-CCP positive individuals with musculoskeletal symptoms but no clinical synovitis.
This study assesses whether the administration route of glucocorticoids in early rheumatoid arthritis influences continued steroid use and advanced therapy initiation at one year.
This article explores how intestinal flagellin drives systemic inflammation via the TLR5-IL-15-ARA pathway in long COVID, rheumatoid arthritis, ankylosing spondylitis, and IBD, highlighting potential therapeutic targets and biomarkers.
Flagellated gut bacteria activate TLR5 on neutrophils, triggering IL-15 release and macrophage arachidonic acid production, driving systemic inflammation in long COVID, rheumatoid arthritis, ankylosing spondylitis, and IBD.
High-sensitivity flow cytometry reveals that early plasmablast depletion predicts 5-year rituximab response in rheumatoid arthritis, while incomplete memory B-cell depletion signals poly-refractory disease.
This study examines lung transplantation patterns, associated risk factors, and post-transplant survival among rheumatoid arthritis-related interstitial lung disease patients in Ontario, revealing key clinical insights under a universal hea
A case series assessing the safety and efficacy of low-dose blinatumomab in 15 patients with multidrug-resistant rheumatoid arthritis showed synovial B-cell depletion, reduced disease activity, and improved response to previously ineffectiv
The RAMUS study demonstrates that the JAK inhibitor tofacitinib significantly increases lower limb muscle volume in patients with rheumatoid arthritis, offering a potential explanation for associated creatinine elevations and a new therapeu
The RAMUS study demonstrates that tofacitinib significantly increases lower limb muscle volume in rheumatoid arthritis patients, potentially explaining associated creatinine elevations and offering a new therapeutic avenue for combating mus
This article examines the prevalence, risk factors, and diagnostic screening strategies for rheumatoid arthritis-associated interstitial lung disease (RA-ILD) in early rheumatoid arthritis, highlighting age and disease activity as key predi
Methotrexate-induced osteopathy, predominantly affecting postmenopausal women with rheumatoid or psoriatic arthritis, presents as stress fractures in the lower limbs. Early MRI or bone scintigraphy aids diagnosis, and discontinuing methotre
This cohort study reveals that low-grade MRI-detected inflammation in hand, wrist, and forefoot joints is common in healthy individuals and at-risk groups, underscoring challenges in distinguishing rheumatoid arthritis-specific inflammation
CPL’116, a novel dual JAK and ROCK inhibitor, demonstrates dose-dependent efficacy and a favorable safety profile in rheumatoid arthritis patients inadequately responsive to methotrexate, without the typical lipid or creatine kinase a
A recent RCT suggests intermittent fasting may improve physical function and disease activity in overweight and obese postmenopausal women with RA, but shows no significant effect on inflammation or oxidative stress markers.
A phase 3 trial indicates that fMRI-detected CNS pain activation may predict which rheumatoid arthritis patients respond best to TNF inhibitor therapy.
