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MedXY AI/MedXY News/Tag: prognostic biomarkers
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TP53 Mutations in Acute Myeloid Leukemia: Impact on Outcomes Post-Allogeneic Hematopoietic Cell Transplantation
Hematology-Oncologyprognostic biomarkersAllogeneic Hematopoietic Cell Transplantation

TP53 Mutations in Acute Myeloid Leukemia: Impact on Outcomes Post-Allogeneic Hematopoietic Cell Transplantation

By MedXY|Sep 11, 2026

TP53 mutations define a high-risk AML subset with inferior survival post-allo-HCT, driven mainly by relapse. Molecular heterogeneity may guide personalized post-transplant strategies.

Decoding the Tumor Immune Microenvironment in Diffuse Large B-Cell Lymphoma: Prognostic Insights from CD163 and CD11c Profiling
Hematology-OncologyTumor immune microenvironment
prognostic biomarkers

Decoding the Tumor Immune Microenvironment in Diffuse Large B-Cell Lymphoma: Prognostic Insights from CD163 and CD11c Profiling

By MedXY|Aug 11, 2026

This study identifies distinct tumor immune microenvironment subgroups in diffuse large B-cell lymphoma based on CD163 and CD11c expression, revealing prognostic significance and potential therapeutic stratification with checkpoint inhibito

Revolutionizing Stage II Colorectal Cancer Prognostication: Validating Semantically-Enhanced AI for Risk Stratification
Gastroenterologyprognostic biomarkersdeep learning

Revolutionizing Stage II Colorectal Cancer Prognostication: Validating Semantically-Enhanced AI for Risk Stratification

By MedXY|Aug 4, 2026

A novel AI model, SÉMIL, integrating vision-language and multiple instance learning, improves prognostic accuracy for stage II colorectal cancer by refining risk stratification beyond current clinical assessments, especially within NCCN hig

TP53 Alterations Emerge as Critical Adverse Prognostic Factor in Pediatric and Young Adult Patients Treated with CD19-CAR T-Cell Therapy for Relapsed/Refractory B-ALL
Hematology-OncologyB細胞急性リンパ性白血病CAR T-cell therapy

TP53 Alterations Emerge as Critical Adverse Prognostic Factor in Pediatric and Young Adult Patients Treated with CD19-CAR T-Cell Therapy for Relapsed/Refractory B-ALL

By MedXY|Apr 12, 2026

A single-center retrospective study of 69 pediatric and young adult patients with relapsed/refractory B-cell acute lymphoblastic leukemia reveals that TP53 alterations significantly compromise outcomes following tisagenlecleucel therapy. Pa

Beyond Simple Quantification: How AI and Tumor-Stroma Ratio Are Redefining Prognosis Prediction in Hepatocellular Carcinoma
newsartificial intelligenceComputational Pathology

Beyond Simple Quantification: How AI and Tumor-Stroma Ratio Are Redefining Prognosis Prediction in Hepatocellular Carcinoma

By MedXY|Apr 9, 2026

Researchers have developed an AI-powered framework that uncovers a non-linear relationship between tumor-stroma ratio and mortality in hepatocellular carcinoma, using a novel token-guided multimodal fusion approach to improve prognostic acc

AI-Derived Body Composition Analysis Unveils Muscle Volume, Metformin-Associated Adipose Effects, and the Obesity Paradox in NSCLC: Clinical and Molecular Insights
Clinical UpdatesAIbody composition

AI-Derived Body Composition Analysis Unveils Muscle Volume, Metformin-Associated Adipose Effects, and the Obesity Paradox in NSCLC: Clinical and Molecular Insights

By MedXY|Nov 17, 2025

AI-driven analysis identifies muscle volume as a robust predictor of survival in NSCLC, highlights metformin-modulated adipose effects, and elucidates molecular links to the obesity paradox, informing personalized prognosis beyond BMI.

Persistent Depressive Symptoms After MCI Strongly Predict Progression to Alzheimer’s Disease
NeurologyAlzheimer's diseasedepression

Persistent Depressive Symptoms After MCI Strongly Predict Progression to Alzheimer’s Disease

By MedXY|Nov 5, 2025

In an ADNI longitudinal cohort, persistently elevated depressive symptoms over 36 months after MCI diagnosis were associated with a dose‑dependent, substantially higher hazard of conversion to Alzheimer’s disease over long-term follow-up.

Evaluating Radiologic Extranodal Extension in HPV-Positive Oropharyngeal Cancer: Accuracy, Prognostic Value, and Clinical Implications from a Multinational Real-World Study
OncologyExtranodal Extensionprognostic biomarkers

Evaluating Radiologic Extranodal Extension in HPV-Positive Oropharyngeal Cancer: Accuracy, Prognostic Value, and Clinical Implications from a Multinational Real-World Study

By MedXY|Oct 22, 2025

This multinational real-world study reveals limited sensitivity and prognostic value of radiologic extranodal extension (iENE) in HPV-positive oropharyngeal cancer, highlighting the enhanced accuracy with combined CT and MRI and the need fo

Early ctDNA Variation as a Prognostic Biomarker in dMMR/MSI-H Metastatic Colorectal Cancer Treated with Immune Checkpoint Inhibitors: Insights from the SAMCO-PRODIGE 54 Trial
OncologyctDNAimmune checkpoint inhibitors

Early ctDNA Variation as a Prognostic Biomarker in dMMR/MSI-H Metastatic Colorectal Cancer Treated with Immune Checkpoint Inhibitors: Insights from the SAMCO-PRODIGE 54 Trial

By MedXY|Oct 4, 2025

A secondary analysis of the SAMCO-PRODIGE 54 trial reveals that early changes in circulating tumor DNA predict long-term outcomes in dMMR/MSI-H metastatic colorectal cancer patients treated with immune checkpoint inhibitors.

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