AI-Derived Body Composition Analysis Unveils Muscle Volume, Metformin-Associated Adipose Effects, and the Obesity Paradox in NSCLC: Clinical and Molecular Insights
Highlights
- Muscle volume measured by AI-driven CT segmentation exhibits a dose-dependent association with overall survival in NSCLC patients.
- The survival benefit of muscle volume is amplified in patients with elevated BMI and diabetes, underscoring a nuanced obesity paradox.
- Subcutaneous and intramuscular adipose tissues predict improved survival exclusively in metformin users, indicating therapeutic metabolic modulation.
- Molecular analyses reveal KRAS mutation enrichment in patients with higher adiposity and EGFR mutation with lower adiposity, linking genotype with body composition phenotypes.
Background
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This article was created using several editorial tools, including AI, as part of the process. Human editors reviewed this content before publication.