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GLP1R R131Q Variant: A Genetic Key to Preserving β-Cell Function and Enhancing GLP-1RA Efficacy in Type 2 Diabetes
Diabetes & Endocrinologypharmacogeneticsβ-cell function

GLP1R R131Q Variant: A Genetic Key to Preserving β-Cell Function and Enhancing GLP-1RA Efficacy in Type 2 Diabetes

By MedXY|Aug 26, 2026

The gain-of-function GLP1R R131Q variant slows β-cell decline and improves glycemic response to GLP-1 receptor agonists, highlighting its potential role in precision diabetes therapeutics.

Genetic Variant in CUBN Gene Identified as Key Risk Factor for Metformin-Induced Vitamin B12 Deficiency
Diabetes & EndocrinologyCUBN Genemetformin

Genetic Variant in CUBN Gene Identified as Key Risk Factor for Metformin-Induced Vitamin B12 Deficiency

By MedXY|Apr 17, 2026

Researchers have identified a genetic variant in the cubilin gene (CUBN, rs1801222) that significantly increases the risk of metformin-induced vitamin B12 deficiency, with carriers of the AA genotype experiencing deficiency up to twice as f

Precision Dosing Without Compromise: UGT1A1 Genotype-Guided Irinotecan Dosing Maintains Survival in Gastrointestinal Cancers
GastroenterologyIrinotecanoncology

Precision Dosing Without Compromise: UGT1A1 Genotype-Guided Irinotecan Dosing Maintains Survival in Gastrointestinal Cancers

By MedXY|Mar 4, 2026

A multicentre cohort study confirms that upfront 30% irinotecan dose reductions for UGT1A1 poor metabolisers effectively prevent severe toxicity without compromising progression-free or overall survival in colorectal and pancreatic cancer p

IL23R Polymorphism as a Genetic Predictor of Paradoxical Psoriasis in Anti-TNFα-Treated IBD Patients
Dermatologyinflammatory bowel diseasepharmacogenetics

IL23R Polymorphism as a Genetic Predictor of Paradoxical Psoriasis in Anti-TNFα-Treated IBD Patients

By MedXY|Oct 9, 2025

The IL23R1142G>A genetic variant strongly predicts paradoxical psoriasis in inflammatory bowel disease patients undergoing anti-TNFα therapy, guiding personalized treatment decisions.

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