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Perioperative Code Status Limitations and Early Postoperative Mortality: Insights from a Multicenter Retrospective Cohort Study
Anesthesiologycode statusperioperative care

Perioperative Code Status Limitations and Early Postoperative Mortality: Insights from a Multicenter Retrospective Cohort Study

By MedXY|Sep 15, 2026

This study investigates the association between continuation of non-full code status during surgery and early postoperative mortality, revealing higher mortality risk that aligns with clinical care decisions rather than missed rescue opport

Transforming Readmission Risk After Colorectal Surgery in Older Adults: From Nonmodifiable to Actionable Geriatric and Comorbidity Factors
General SurgerygeriatricsComorbidities

Transforming Readmission Risk After Colorectal Surgery in Older Adults: From Nonmodifiable to Actionable Geriatric and Comorbidity Factors

By MedXY|Aug 25, 2026

This study highlights that geriatric vulnerabilities and comorbidities, once considered nonmodifiable, play a dominant role in 30-day readmissions after colorectal surgery in older adults, emphasizing the need for integrated perioperative i

Low-Yield or High-Value? Preoperative Cardiac Workup in Children With Very Severe OSA
newsadenotonsillectomycardiac workup

Low-Yield or High-Value? Preoperative Cardiac Workup in Children With Very Severe OSA

By MedXY|Jun 19, 2026

Preoperative cardiac testing in children with very severe OSA had low diagnostic yield and rarely changed management. Risk appeared highest in obese adolescents with AHI >50 events/hour.

AnesthesiologyDiabetes MellitusHbA1c

European Perioperative Diabetes Care: Significant Practice Variation Impacts 30-Day Recovery Outcomes

By MedXY|Dec 19, 2025

The MOPED study of over 6,000 European patients reveals significant international variations in perioperative diabetes management. Findings demonstrate that higher preoperative HbA1c levels and practice inconsistencies are linked to fewer d

Home-Based Prehabilitation Did Not Reduce Disability or Complications in Older Adults with Frailty: Results of a Pragmatic Multicenter RCT
AnesthesiologyFrailtyperioperative care

Home-Based Prehabilitation Did Not Reduce Disability or Complications in Older Adults with Frailty: Results of a Pragmatic Multicenter RCT

By MedXY|Dec 9, 2025

A pragmatic multicenter randomized trial found that coach-supported, home-based multimodal prehabilitation before elective noncardiac surgery did not reduce 30-day postoperative disability or in-hospital complications in older adults with f

Biomarker-Guided Preventive Care Halves Risk of Moderate–Severe AKI After Major Surgery: Results from BigpAK-2
Critical Careacute kidney injurybiomarkers

Biomarker-Guided Preventive Care Halves Risk of Moderate–Severe AKI After Major Surgery: Results from BigpAK-2

By MedXY|Nov 25, 2025

In BigpAK-2, a multinational randomized trial, a KDIGO-based preventive bundle triggered by tubular stress biomarkers reduced moderate or severe acute kidney injury within 72 hours after major surgery (OR 0.57; NNT 12) without increasing ad

Metformin Exposure Associated with Up to 81% Lower 30‑Day Mortality After Cardiac Surgery in T2DM: A Critical Appraisal of AHA 2025 MIMIC‑IV Cohort Findings
Cardiologycardiac surgerymetformin

Metformin Exposure Associated with Up to 81% Lower 30‑Day Mortality After Cardiac Surgery in T2DM: A Critical Appraisal of AHA 2025 MIMIC‑IV Cohort Findings

By MedXY|Nov 13, 2025

A retrospective MIMIC‑IV cohort presented at AHA 2025 found perioperative metformin exposure in T2DM patients undergoing cardiac surgery associated with markedly lower 30‑, 90‑ and 360‑day mortality. Results are compelling but observational

Liberal vs Restrictive Postoperative Transfusion in High-Cardiac-Risk Surgery: TOP Trial Shows No Mortality or Major Ischemic Benefit
Cardiologyperioperative caretransfusion thresholds

Liberal vs Restrictive Postoperative Transfusion in High-Cardiac-Risk Surgery: TOP Trial Shows No Mortality or Major Ischemic Benefit

By MedXY|Nov 10, 2025

In high–cardiac-risk veterans after major vascular or general surgery, a liberal postoperative transfusion threshold (Hb <10 g/dL) did not reduce 90‑day death or major ischemic events compared with a restrictive threshold (Hb <7 g/dL)

Evaluating the Impact of a Perioperative Care Bundle on Surgical Site Infection Prevention After Abdominal Surgery: Insights from the EPO2CH Trial
General Surgeryperioperative care

Evaluating the Impact of a Perioperative Care Bundle on Surgical Site Infection Prevention After Abdominal Surgery: Insights from the EPO2CH Trial

By MedXY|Oct 18, 2025

This comprehensive review explores the EPO2CH trial, which assessed a multi-component care bundle’s effectiveness in reducing surgical site infections after abdominal surgery, highlighting key findings, limitations, and clinical impli

Ivabradine Fails to Reduce Myocardial Injury After Noncardiac Surgery: Insights from a Large RCT
Cardiologymyocardial injurynoncardiac surgery

Ivabradine Fails to Reduce Myocardial Injury After Noncardiac Surgery: Insights from a Large RCT

By MedXY|Oct 6, 2025

A large randomized trial shows that ivabradine, despite effectively lowering heart rate during surgery, does not reduce myocardial injury after noncardiac surgery, highlighting the complexity of perioperative cardiac risk management.

CBD Use Among Elective Sports Surgery Patients Highlights Demand for Opioid Alternatives in Pain and Sleep Management
Clinical Updatespain managementperioperative care

CBD Use Among Elective Sports Surgery Patients Highlights Demand for Opioid Alternatives in Pain and Sleep Management

By MedXY|Sep 30, 2025

A recent survey found 39% of elective sports surgery patients used CBD for pain or sleep, with one-third reporting benefit—underscoring the need for more evidence and opioid alternatives.

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