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MedXY AI/MedXY News/Tag: pancreatic ductal adenocarcinoma
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Trogocytosis-Mediated CLDN18.2 Acquisition by CD8+ T Cells Impairs Anti-Tumor Immunity and Drives Pancreatic Cancer Progression
newspancreatic ductal adenocarcinomaCD8+ T cells

Trogocytosis-Mediated CLDN18.2 Acquisition by CD8+ T Cells Impairs Anti-Tumor Immunity and Drives Pancreatic Cancer Progression

By MedXY|Sep 17, 2026

This study reveals that CLDN18.2 acquired by CD8+ T cells through trogocytosis impairs their glucose metabolism and cytotoxic function, promoting pancreatic cancer progression and systemic immune senescence. Targeting this axis may enhance

Real-World Five-Year Survival After Neoadjuvant Therapy and Surgery in Localized Pancreatic Ductal Adenocarcinoma
General Surgeryrecurrence
five-year survival

Real-World Five-Year Survival After Neoadjuvant Therapy and Surgery in Localized Pancreatic Ductal Adenocarcinoma

By MedXY|Sep 15, 2026

This study reveals that over one-third of patients with localized PDAC receiving neoadjuvant therapy and surgery achieve actual five-year survival, highlighting the impact of early systemic failure and identifying factors predicting long-te

Neoadjuvant Chemotherapy with or without Radiotherapy in Resected Pancreatic Ductal Adenocarcinoma: Impact on Outcomes
General Surgerysurvival outcomesRadiotherapy

Neoadjuvant Chemotherapy with or without Radiotherapy in Resected Pancreatic Ductal Adenocarcinoma: Impact on Outcomes

By MedXY|Aug 31, 2026

A propensity-matched study shows adding radiotherapy to neoadjuvant chemotherapy improves pathologic response but does not enhance survival or reduce recurrence in resected pancreatic ductal adenocarcinoma.

Targeting NSUN6 Deficiency to Overcome Immune Suppression in Pancreatic Cancer: Insights into the KDM5A-CCL2-Macrophage Axis
GastroenterologyCCL2Macrophages

Targeting NSUN6 Deficiency to Overcome Immune Suppression in Pancreatic Cancer: Insights into the KDM5A-CCL2-Macrophage Axis

By MedXY|Aug 21, 2026

NSUN6 deficiency in pancreatic cancer promotes immune suppression by enhancing immunosuppressive macrophage infiltration via the KDM5A-CCL2 axis, leading to resistance to immune checkpoint blockade; targeting this pathway offers a promising

Targeting SMPD1-Driven Sphingolipid Metabolism to Disrupt KRAS Signaling in Pancreatic Ductal Adenocarcinoma
GastroenterologygastroenterologyKRAS

Targeting SMPD1-Driven Sphingolipid Metabolism to Disrupt KRAS Signaling in Pancreatic Ductal Adenocarcinoma

By MedXY|Jul 8, 2026

This study reveals that dysregulated sphingolipid metabolism via SMPD1 supports KRAS-driven pancreatic cancer progression, identifying SMPD1 as a promising therapeutic target in pancreatic ductal adenocarcinoma.

AI Radiomics Detects Visually Occult Pancreatic Cancer on CT Nearly 16 Months Before Diagnosis and Outperforms Radiologists
AIComputed tomographyearly detection AI

AI Radiomics Detects Visually Occult Pancreatic Cancer on CT Nearly 16 Months Before Diagnosis and Outperforms Radiologists

By MedXY|May 4, 2026

A multi-institutional AI model identified pre-diagnostic pancreatic cancer on routine CT with meaningful lead time, higher sensitivity than radiologists, longitudinal stability, and externally validated specificity in a low-prevalence setti

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