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Harnessing Type-I Interferon-Activated NK Cells: A Novel Immunotherapeutic Approach to Polycythemia Vera
Hematology-OncologyJak2VF mutationNatural Killer Cells

Harnessing Type-I Interferon-Activated NK Cells: A Novel Immunotherapeutic Approach to Polycythemia Vera

By MedXY|Sep 18, 2026

This article explores how type-I interferon activates NK cells to control polycythemia vera progression, revealing insights into immune modulation and therapeutic potential in myeloproliferative neoplasms.

Functional Impairment of Natural Killer Cells After Severe Trauma: Phenotypic Shifts and Loss of Activating Receptors
Allergy & ImmunologyActivating ReceptorsNatural Killer Cells

Functional Impairment of Natural Killer Cells After Severe Trauma: Phenotypic Shifts and Loss of Activating Receptors

By MedXY|Aug 11, 2026

Severe trauma induces maturation and cytotoxic phenotypes in NK cells but paradoxically decreases expression of activating receptors critical for immune defense, revealing a mechanism underlying posttrauma immune dysregulation and vulnerabi

Dynamic Alterations in Natural Killer Cell Phenotype and Activating Receptor Expression Following Trauma: Insights into Immune Dysregulation
Allergy & ImmunologyActivating ReceptorsNatural Killer Cells

Dynamic Alterations in Natural Killer Cell Phenotype and Activating Receptor Expression Following Trauma: Insights into Immune Dysregulation

By MedXY|Aug 11, 2026

Severe trauma induces phenotypic maturation of natural killer cells but leads to a loss of key activating receptors, potentially driving posttraumatic immune dysfunction and increased infection risk.

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