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A randomized clinical trial finds that a 6-week ketogenic diet provides modest antidepressant effects for treatment-resistant depression compared to a healthy control diet, though long-term clinical relevance and impact on secondary outcome
A 3-year observational study demonstrates that a remotely delivered ketogenic nutrition program leads to sustained improvements in glycemic control, weight, medication use, and metabolic markers among US veterans with type 2 diabetes.
A randomized, double‑blind pilot tested an MCT‑supplemented ketogenic diet (MCT‑KD) in 16 people with moderate Parkinson’s disease. The diet was feasible and acceptable, induced nutritional ketosis by day 4, produced metabolic benefits and
The KIWE randomised trial (Lancet Neurol 2023) found no superiority of a classic ketogenic diet over an additional antiseizure medication for seizure frequency in infants (1–24 months) with drug‑resistant epilepsy; tolerability and safety p
This trial demonstrates that a ketogenic diet safely induces stable ketosis in sepsis patients, improving metabolic parameters and immune regulation without adverse effects, suggesting potential benefits for sepsis-related organ dysfunction
A 12-week RCT reveals that ketogenic, but not free-sugar-restricted, diets significantly alter glucose tolerance, lipid metabolism, skeletal muscle phenotype, and gut microbiome in healthy adults, despite similar fat mass reductions.
A 3-week ketogenic diet improved skeletal muscle insulin sensitivity and promoted weight loss in individuals with obesity, without significant effects on liver or adipose tissue insulin sensitivity.
Serum metabolome and gut microbiota changes during ketogenic diet therapy correlate with seizure reduction in drug-resistant pediatric epilepsy, implicating plasmalogens and specific gut microbes in anti-seizure effects.
A head-to-head comparison of ketogenic and Mediterranean diets demonstrates comparable benefits on weight, blood pressure, and metabolic health in overweight hypertensive adults over three months.
This clinical trial compares the weight loss effects of ketogenic diet, time-restricted eating, and alternate-day fasting against a Mediterranean diet in adults with obesity over three months.