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A post hoc analysis of the BRIDGE-TNK trial reveals that intravenous tenecteplase before endovascular thrombectomy significantly improves functional independence in acute large-vessel occlusion stroke patients with extensive baseline ischem
Thrombus perviousness influences clinical outcomes in medium vessel occlusion strokes, with higher perviousness favoring intravenous thrombolysis and lower perviousness favoring endovascular therapy.
A large multinational RES-Q registry analysis suggests that the benefit of bridging thrombolysis before thrombectomy is greatest when treatment starts very early, with attenuation after 150 minutes.
A multicenter retrospective cohort found that IV thrombolysis started beyond 4.5 hours and before interhospital transfer for EVT was associated with higher rates of spontaneous recanalization during transfer and better 3‑month functional ou
A multicenter retrospective cohort (OPEN-WINDOW) found that IV thrombolysis given beyond 4.5 hours before interhospital transfer for EVT was associated with higher rates of recanalization during transfer and better 3‑month functional outcom
A secondary analysis of the TEMPO-2 trial shows that intravenous tenecteplase does not improve 90-day outcomes in minor disabling stroke defined by NIHSS scores, highlighting the need to reconsider thrombolysis in this patient population.
