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Nationwide analyses show that epilepsy markedly increases the risk of young-onset dementia (YOD) before age 65, with persistent associations even years after epilepsy diagnosis, underscoring the need for YOD risk assessment in epilepsy care
This article examines the prevalent coprescription of enzyme-inducing antiseizure medications (ASMs) and susceptible hormonal contraceptives among US Medicaid beneficiaries with epilepsy, highlighting patient risk factors and implications f
A comprehensive cohort study from the EURAP registry reveals that antiseizure medication, especially polytherapy and certain monotherapies, increases the risk of poor fetal growth, underscoring the need for optimized treatment strategies du
This study reveals distinct thromboembolic, bleeding, and mortality risks based on antiseizure medication selection in epilepsy patients receiving direct oral anticoagulants, highlighting the critical role of ASM choice on patient safety an
This study develops a comprehensive probabilistic atlas of brain function using extraoperative electrocortical stimulation mapping in epilepsy patients, revealing distributed and variable language and motor cortical organization beyond trad
An Australian cohort study found that prenatal exposure to valproate, levetiracetam, topiramate, and carbamazepine was associated with poorer cognitive outcomes in children, while lamotrigine exposure was not.
A national U.S. study found that patients with epilepsy from rural counties had worse hospital outcomes, including higher mortality, more status epilepticus, longer stays, and less EEG use, highlighting access-related disparities.
This article examines a Phase 2a trial investigating eslicarbazepine acetate for preventing post-stroke epilepsy. While the primary endpoint was not met due to recruitment challenges, the study provides a critical framework for future antie
Researchers developed EEGSurvNet, a deep survival model that analyzes routine EEG to predict seizure risk over two years. Outperforming clinical models, it achieved an AUROC of 0.80 at two months and showed high efficacy in patients without
This case-control study identifies altered slow-wave activity progression and increased respiratory variability during NREM sleep as significant biomarkers for SUDEP risk, providing a potential framework for objective clinical screening and
A Cochrane review finds limited and low- to moderate-certainty evidence that behavioural, self-management, or service delivery interventions improve seizure control or quality of life in adults with epilepsy.
Current evidence for behavioural and service delivery interventions in childhood epilepsy is scarce and of low quality, highlighting an urgent need for rigorous, long-term trials.
A Medicare cohort study mapped incident epilepsy among older adults across the contiguous US and linked high-incidence areas to social and environmental determinants—most strongly insufficient sleep and lack of household vehicle access—sugg
A decade-long prospective study identifies living alone, convulsive seizure frequency, and peri-ictal apnoea as pivotal predictors for sudden unexpected death in epilepsy (SUDEP), highlighting the potential of cardiorespiratory monitoring i
Serum metabolome and gut microbiota changes during ketogenic diet therapy correlate with seizure reduction in drug-resistant pediatric epilepsy, implicating plasmalogens and specific gut microbes in anti-seizure effects.
