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This article reviews a 13-year longitudinal study assessing blood-based biomarkers’ effectiveness in predicting all-cause dementia among community-dwelling older adults, highlighting their modest sensitivity and enhanced predictive value wh
This study examines how the 2016 CDC opioid prescribing guideline influenced opioid and gabapentinoid use in older adults with dementia, revealing shifts in analgesic prescribing patterns but uncertain effects on symptom management.
A comprehensive cohort study demonstrates that ADHD significantly increases the risk of mild cognitive impairment and dementia in older adults, highlighting the need for targeted monitoring and integrated care in this vulnerable population.
Clinicians face multifaceted challenges during surgical decision-making for patients with dementia, including difficulties in dementia recognition, reliance on caregivers, and lack of evidence-based guidelines, underscoring the need for imp
This article explores the complex challenges clinicians face in surgical decision-making for patients with dementia, highlighting issues with dementia identification, caregiver roles, and the influence of dementia on surgical outcomes.
Brain-predicted age difference (brain-PAD) from MRI improves early dementia risk prediction in patients with subjective cognitive decline, outperforming traditional visual MRI ratings and offering prognostic value beyond amyloid biomarkers,
Among older adults with incident dementia, Alzheimer disease and LATE-NC pathologies were independently linked to higher odds of receiving a timely diagnosis, while vascular pathology and Lewy bodies showed no significant association.
Highlight Agitation is prevalent among dementia patients in nursing homes, often managed with pharmacologic agents....
This study reveals that dementia in severe, treatment-resistant schizophrenia exhibits a unique cognitive profile distinct from common neurodegenerative dementias and lacks typical genetic markers such as APOE4, highlighting a novel dementi
This article explores how physicians determine stroke care goals for patients with disability or dementia, highlighting key challenges, decision factors, and the need for individualized, bias-aware approaches.
Wearable accelerometer sleep-wake patterns were linked to later dementia risk in two UK cohorts and modestly improved prediction beyond age and standard risk factors.
In older adults with limited small vessel disease, “dirty-appearing” white matter on MRI was not linked to baseline cognition, cognitive decline, or dementia risk, unlike conventional white matter hyperintensities.
A landmark South Korean study of 2.8 million adults reveals that both elevated blood pressure and hypertension significantly increase dementia risk, particularly vascular dementia, with stronger effects observed in midlife adults and women.
A retrospective cohort study reveals that dementia patients with preferred language other than English are more likely to have documented goals-of-care discussions yet experience significantly higher hospital-based healthcare utilization ne
Four men exposed in childhood to cadaveric pituitary-derived human growth hormone developed dementia decades later; one autopsied case showed severe Alzheimer-type pathology, including tauopathy, supporting a transmissible iatrogenic Alzhei
This review analyzes multinational data showing a significant decline in cardiovascular mortality among diabetes patients, alongside a concerning rise in dementia-related deaths and the emergence of cancer as a leading cause of mortality in
A large-scale longitudinal study reveals that over 80% of community-dwelling older adults harbor mixed neuropathologies, identifying five distinct profiles that dictate specific cognitive decline trajectories, with ADNC and LATE-NC clusters
This population-based cohort study highlights how cumulative psychosocial stress across the life course significantly escalates the risk of neurovascular and neurodegenerative diseases, identifying depression as a critical target for interv
A prospective study of over 130,000 adults reveals that consuming 2-3 cups of caffeinated coffee or 1-2 cups of tea daily significantly reduces dementia risk and cognitive decline, whereas decaffeinated coffee shows no protective effect.
A longitudinal study of 12,268 participants reveals that women are more susceptible to cognitive decline and dementia when burdened by high blood pressure and the APOE ε4 allele compared to men.
