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Unraveling the Link Between Alzheimer’s Pathology, Sleep Disturbances, and Cognitive Decline in Late-Onset Unexplained Epilepsy
NeurologycognitionAlzheimer pathology

Unraveling the Link Between Alzheimer’s Pathology, Sleep Disturbances, and Cognitive Decline in Late-Onset Unexplained Epilepsy

By MedXY|Sep 5, 2026

Elevated plasma p-tau217 correlates with cognitive impairment and altered sleep microarchitecture in older adults with late-onset unexplained epilepsy, highlighting potential pathways linking neurodegeneration, epilepsy severity, and sleep

Bridging Social Determinants of Health and Multidimensional Frailty Among Older Adults: A Domain-Specific Latent Class and Network Analysis
Neurologycognition
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public health

Bridging Social Determinants of Health and Multidimensional Frailty Among Older Adults: A Domain-Specific Latent Class and Network Analysis

By MedXY|Aug 26, 2026

This study explores how economic, educational, healthcare, neighborhood, and social factors link to multiple frailty dimensions in Chinese older adults, highlighting cognition as a key intermediary.

Decoding Sleep’s Role in Cognitive Health and Dementia Risk: Insights from the Sleep and Dementia Consortium
Neurologycognitioncognitive performance

Decoding Sleep’s Role in Cognitive Health and Dementia Risk: Insights from the Sleep and Dementia Consortium

By MedXY|Jul 31, 2026

This study identifies distinct sleep patterns linked to cognitive performance but finds no significant direct association with dementia risk, highlighting the complexity of sleep-cognition relationships in aging populations.

Long-Term Mortality, Cognition, and Quality of Life After Chronic Subdural Hematoma Surgery: A Comprehensive Review
Clinical Updateschronic subdural hematomacognition

Long-Term Mortality, Cognition, and Quality of Life After Chronic Subdural Hematoma Surgery: A Comprehensive Review

By MedXY|Jun 25, 2026

This review synthesizes evidence on the long-term survival, excess mortality, and health-related quality of life in patients after chronic subdural hematoma surgery, emphasizing sustained mortality risks and cognitive-physical deficits up t

Long-Term Cognitive Recovery After Stroke: What the Oxford Cognitive Screen Reveals
NeurologycognitionOxford Cognitive Screen

Long-Term Cognitive Recovery After Stroke: What the Oxford Cognitive Screen Reveals

By MedXY|May 20, 2026

A long-term stroke study found that cognition improves most within 6 months, with memory and language recovering better than executive function. Early cognitive impairment was the strongest predictor of outcomes years later.

Patient-Derived Neuronal Synapse Deficits Predict Brain Network Abnormalities and Cognitive Impairment in Schizophrenia
NeurologycognitioniPSC

Patient-Derived Neuronal Synapse Deficits Predict Brain Network Abnormalities and Cognitive Impairment in Schizophrenia

By MedXY|May 15, 2026

A multimodal translational study links genetically driven synaptic deficits in patient-derived neurons to cortical structure, electrophysiology, and cognition in schizophrenia, supporting biologically informed stratification of cognitive im

Polygenic Influences and Anticholinergic Burden: Unraveling Their Joint Impact on Cognition and Brain Structure in Psychosis Spectrum Disorders
Neurologybrain structurecognition

Polygenic Influences and Anticholinergic Burden: Unraveling Their Joint Impact on Cognition and Brain Structure in Psychosis Spectrum Disorders

By MedXY|Oct 30, 2025

This study reveals that genetic predispositions interact with anticholinergic medication burden to influence cognitive deficits and brain gray matter volume reductions in psychosis spectrum disorders, offering new insights into personalized

Moderate-to-Vigorous Physical Activity, p-tau181, and Cognition in Older Adults with Memory Complaints: Insights from the MAPT Study
NeurologyagingAlzheimer's disease

Moderate-to-Vigorous Physical Activity, p-tau181, and Cognition in Older Adults with Memory Complaints: Insights from the MAPT Study

By MedXY|Oct 20, 2025

Higher moderate-to-vigorous physical activity slows p-tau181 increase, a marker of Alzheimer’s pathology, but elevated p-tau181 diminishes exercise-related cognitive benefits in older adults.

Life Course Air Pollution Exposure Linked to Cognitive Decline and Brain Structural Changes in Older Adults
Neurologyagingair pollution

Life Course Air Pollution Exposure Linked to Cognitive Decline and Brain Structural Changes in Older Adults

By MedXY|Oct 20, 2025

A population-based study reveals that midlife exposure to air pollutants such as nitrogen dioxide and particulate matter is associated with cognitive decline and brain structural alterations by age 69-71, highlighting long-term neurological

Life Course Air Pollution Exposure and Cognitive Decline: Insights from the 1946 British Birth Cohort
Neurologyagingair pollution

Life Course Air Pollution Exposure and Cognitive Decline: Insights from the 1946 British Birth Cohort

By MedXY|Oct 20, 2025

This population-based study reveals that midlife exposure to nitrogen dioxide and particulate matter correlates with poorer cognitive function and adverse brain structural changes in later life, underscoring the neurocognitive risks of air

Cardiorespiratory Exercise Enhances Cognitive Function After Ischemic Stroke: Insights from the PISCES-ZODIAC Trial
Neurologycognitionhippocampal volume

Cardiorespiratory Exercise Enhances Cognitive Function After Ischemic Stroke: Insights from the PISCES-ZODIAC Trial

By MedXY|Oct 5, 2025

An 8-week cardiorespiratory exercise program initiated 2 months after ischemic stroke improved cognitive performance at 12 months, despite no significant preservation of hippocampal volume compared with control. The intervention was safe an

Walking and Dietary Interventions Offer Cognitive Protection in APOE ε4 Carriers: New Evidence from Longitudinal and Multinational Trials
Clinical UpdatesAlzheimer's diseaseAPOE ε4

Walking and Dietary Interventions Offer Cognitive Protection in APOE ε4 Carriers: New Evidence from Longitudinal and Multinational Trials

By MedXY|Sep 30, 2025

Regular walking and lifestyle interventions slow cognitive decline, especially in APOE ε4 carriers at heightened Alzheimer’s risk, with effects pronounced in women. Evidence underscores the value of simple activity and healthy diet for at-r

Structured Lifestyle Interventions Deliver Superior Cognitive Benefits over Self-Guided Approaches in At-Risk Older Adults
Clinical UpdatescognitionDementia

Structured Lifestyle Interventions Deliver Superior Cognitive Benefits over Self-Guided Approaches in At-Risk Older Adults

By MedXY|Sep 30, 2025

A large phase 3 trial reveals that structured, multidomain lifestyle interventions significantly improve cognition in older adults at risk for cognitive decline, outperforming self-guided strategies.

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